Results 161 to 170 of about 2,772,078 (264)

Total Arch Replacement with Ascyrus Medical Dissection Stent Versus Frozen Elephant Trunk in Acute Type A Aortic Dissection: A Meta-Analysis. [PDF]

J Clin Med
Baudo M, Rosati F, D'Alonzo M, Fiore A, Muneretto C, Benussi S, Di Bacco L.   +6 more
europepmc   +1 more source

E3 ligase Praja1 mediates ubiquitination and degradation of microtubule‐associated protein tau

The FEBS Journal, EarlyView.
E3 ligase Praja1, but not its paralogue Praja2, recognizes and ubiquitinates tau protein for proteasomal degradation. This newly identified function of Praja1‐mediated tau degradation suggests its role in protein quality control, which may provide insights into the pathogenesis of tauopathies.
Shiho Aoki, Wataru Onodera, Akihiko Takashima, Kotaro Kawasaki, Kazuki Imadegawa, Hikaru Kurahashi, Mizuho Oishi, Toru Asahi, Yoshiyuki Soeda   +8 more
wiley   +1 more source

Improvement in Glycemic Metrics With the First and Second Continuous Glucose Monitoring (CGM) Sensor Use in Indian Patients With Type 2 Diabetes Mellitus. [PDF]

Cureus
Gupta V.
europepmc   +1 more source

Co‐localization of tau and TDP‐43 after extracellular vesicle delivery to cells

The FEBS Journal, EarlyView.
Extracellular vesicles (EVs) derived from donor cells transfected with EGFP–2N4R‐tau or mCherry‐wtTDP‐43 were taken up by recipient cells, leading to cytosolic co‐localization of tau and TDP‐43. Molecular modeling revealed that tau and TDP‐43 directly interact through hydrogen bonding, suggesting a mechanistic link underlying their co‐pathology ...
Farhang Aliakbari, Kathryn Volkening, Zahra Nayeri, Aysegul Yucel Polat, Neil Donison, Jacqueline Palik, Michael J. Strong   +6 more
wiley   +1 more source

A digital twin-enhanced decision support system improves time-in-range in type 1 diabetes: a randomized clinical trial. [PDF]

Sci Rep
Builes-Montaño CE, Lema-Perez L, Ramírez-Rincón A, Zuleta-Tobón JJ, Restrepo-Gutiérrez JC, Álvarez-Zapata HD, García-Tirado J.   +6 more
europepmc   +1 more source

The ALS‐associated E425K mutation uncouples DNAJC7 from the Hsp70 chaperone cycle

The FEBS Journal, EarlyView.
DNAJC7 is a J‐domain protein that plays a key role in protein quality control by regulating Hsp70 activity and preventing protein aggregation. We find that the ALS‐associated E425K mutation in DNAJC7 disrupts productive interaction and activation of Hsp70, thereby blocking the transfer and refolding of client proteins such as TDP‐43.
Bar Elmaleh, Ofrah Faust, Rina Rosenzweig   +2 more
wiley   +1 more source

CGM‐derived efficacy and overall safety of once‐weekly insulin efsitora alfa (efsitora) relative to day of administration in adults with type 2 diabetes

Diabetes, Obesity and Metabolism, EarlyView.
Thomas Martens, Tadej Battelino, Simon Heller, Anuj Bhargava, Linong Ji, Sreenivasa Murthy, Rebecca J. Threlkeld, Xiaoqi Li, Ada Leticia Murro, Kristen Syring, Vidhi Patel   +10 more
wiley   +1 more source

Larval Transport Pathways Reveal Critical Habitat and Benefits of a Marine Protected Area to Fisheries

Fisheries Oceanography, EarlyView.
ABSTRACT Quantifying where marine organisms are born and subsequently disperse to is essential for fisheries management. Here, we conducted Lagrangian particle tracking of viviparous rockfish (Sebastes spp.) collected in the Southern California Bight over the course of 16 years.
Lucinda A. Quigley, Peter J. S. Franks, Andrew R. Thompson, Noah Ben‐Aderet, H. William Fennie, Mark M. Morales, Jarrod A. Santora, Eric P. Bjorkstedt   +7 more
wiley   +1 more source

An AI-driven machine learning approach identifies risk factors associated with 30-day mortality following total aortic arch replacement combined with stent elephant implantation. [PDF]

Ann Med
Zhang S, Li L, Wang J, Li Y, Zhou Y, Tao Y, Yu C, Sun X, Guo H, Zhao D, Chang Y, Sun J, Qian X.   +12 more
europepmc   +1 more source

Empowerment for People With Lived Experience of the Justice System? Peer Leadership and the ‘Spectrum of Public Participation’

The Howard Journal of Crime and Justice, EarlyView.
ABSTRACT Drawing from Arnstein's original ladder model, and the political philosophy of Dewey, Fraser and Pitkin, it is argued that people with lived experience of the justice system require a coherent social movement if they are to be collectively empowered by lived experience consultations.
Aaron Hart
wiley   +1 more source