Results 161 to 170 of about 2,772,078 (264)

E3 ligase Praja1 mediates ubiquitination and degradation of microtubule‐associated protein tau

open access: yesThe FEBS Journal, EarlyView.
E3 ligase Praja1, but not its paralogue Praja2, recognizes and ubiquitinates tau protein for proteasomal degradation. This newly identified function of Praja1‐mediated tau degradation suggests its role in protein quality control, which may provide insights into the pathogenesis of tauopathies.
Shiho Aoki   +8 more
wiley   +1 more source

Co‐localization of tau and TDP‐43 after extracellular vesicle delivery to cells

open access: yesThe FEBS Journal, EarlyView.
Extracellular vesicles (EVs) derived from donor cells transfected with EGFP–2N4R‐tau or mCherry‐wtTDP‐43 were taken up by recipient cells, leading to cytosolic co‐localization of tau and TDP‐43. Molecular modeling revealed that tau and TDP‐43 directly interact through hydrogen bonding, suggesting a mechanistic link underlying their co‐pathology ...
Farhang Aliakbari   +6 more
wiley   +1 more source

A digital twin-enhanced decision support system improves time-in-range in type 1 diabetes: a randomized clinical trial. [PDF]

open access: yesSci Rep
Builes-Montaño CE   +6 more
europepmc   +1 more source

The ALS‐associated E425K mutation uncouples DNAJC7 from the Hsp70 chaperone cycle

open access: yesThe FEBS Journal, EarlyView.
DNAJC7 is a J‐domain protein that plays a key role in protein quality control by regulating Hsp70 activity and preventing protein aggregation. We find that the ALS‐associated E425K mutation in DNAJC7 disrupts productive interaction and activation of Hsp70, thereby blocking the transfer and refolding of client proteins such as TDP‐43.
Bar Elmaleh   +2 more
wiley   +1 more source

CGM‐derived efficacy and overall safety of once‐weekly insulin efsitora alfa (efsitora) relative to day of administration in adults with type 2 diabetes

open access: yes
Diabetes, Obesity and Metabolism, EarlyView.
Thomas Martens   +10 more
wiley   +1 more source

Larval Transport Pathways Reveal Critical Habitat and Benefits of a Marine Protected Area to Fisheries

open access: yesFisheries Oceanography, EarlyView.
ABSTRACT Quantifying where marine organisms are born and subsequently disperse to is essential for fisheries management. Here, we conducted Lagrangian particle tracking of viviparous rockfish (Sebastes spp.) collected in the Southern California Bight over the course of 16 years.
Lucinda A. Quigley   +7 more
wiley   +1 more source

Empowerment for People With Lived Experience of the Justice System? Peer Leadership and the ‘Spectrum of Public Participation’

open access: yesThe Howard Journal of Crime and Justice, EarlyView.
ABSTRACT Drawing from Arnstein's original ladder model, and the political philosophy of Dewey, Fraser and Pitkin, it is argued that people with lived experience of the justice system require a coherent social movement if they are to be collectively empowered by lived experience consultations.
Aaron Hart
wiley   +1 more source

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