Structure-Based Computational Database Screening, In Vitro Assay, and NMR Assessment of Compounds that Target TAR RNA [PDF]
Chemistry & Biology, 2002 There has been little prior effort to discover new drugs on the basis of a unique RNA structure. Binding of the viral transactivator Tat to the 5' bulge of the transactivation response (TAR) element is necessary for HIV-1 replication, so TAR RNA is a superb target. A computational approach was developed to screen a large chemical library for binding to
Koh Fujinaga +4 more
openaire +3 more sources
Self-sustaining smouldering combustion of coal tar for the remediation of contaminated sand: Two-dimensional experiments and computational simulations [PDF]
Fuel, 2015 Abstract This study presents the development and validation of a computational model which simulates the propagation of a smouldering front through a porous medium against unique experiments in coal tar and sand. The model couples a multiphase flow solver in porous media with a perimeter expansion module based on Huygens principle to predict the ...
Guillermo Rein +5 more
openaire +5 more sources
Tropical Agricultural Research, 2011 The objective of this study was to determine the association between nutritional status and life-style practices of primary school children in the Colombo district.
RMLR Thilakarathne, DGNG Wijesinghe
doaj +1 more source
Universality and the approach to the continuum limit in lattice gauge theory [PDF]
, 1994 The universality of the continuum limit and the applicability of renormalized perturbation theory are tested in the SU(2) lattice gauge theory by computing two different non-perturbatively defined running couplings over a large range of energies.
de Divitiis +28 more
core +2 more sources
On the Estimation of Euler Equations in the Presence of a Potential Regime Shift [PDF]
, 2003 The concept of a peso problem is formalized in terms of a linear Euler equation and a nonlinear marginal model describing the dynamics of the exogenous driving process.
A. Galli +5 more
core +6 more sources
Bionics of Intelligence, 2018 The mathematical and computer research and optimization of the system "Modified medium (coal tar) - polymer (waste from Pvc production) - active disperse filler (waste coke production - cube residues of distillation of phthalic anhydride)" are carried out.
Oleksiy Povzun +3 more
openaire +3 more sources
FASTQ File Compression Benchmarking Using Lossless General Purpose Algorithms
Practice and Experience in Advanced Research Computing, 2023 FASTQ format is a text-based format for storing a biological sequence (usually nucleotide sequence) and its corresponding quality scores used for genome sequencing.
Erick Joel Mcghee, Stephen Milton
semanticscholar +1 more source
Influence of Reaction Atmosphere (H2O, N2, H2, CO2, CO) on Fluidized-Bed Fast Pyrolysis of Biomass Using Detailed Tar Vapor Chemistry in Computational Fluid Dynamics [PDF]
Industrial & Engineering Chemistry Research, 2015 Secondary pyrolysis in fluidized bed fast pyrolysis of biomass is the focus of this work. A novel computational fluid dynamics (CFD) model coupled with a comprehensive chemistry scheme (134 species and 4169 reactions, in CHEMKIN format) has been developed to investigate this complex phenomenon.
Mellin, Pelle +3 more
openaire +4 more sources
A comparison of CMB- and HLA-based approaches to type I interoperability reference model problems for COTS-based distributed simulation [PDF]
, 2005 Commercial-off-the-shelf (COTS) simulation packages (CSPs) are software used by many simulation modellers to build and experiment with models of various systems in domains such as manufacturing, health, logistics and commerce.
Ayani, R. +16 more
core +1 more source
Journal of Diabetes Science and Technology, 2021 Background: In the management of type 1 diabetes (T1D), systematic and random errors in carb-counting can have an adverse effect on glycemic control. In this study, we performed an in silico trial aiming at quantifying the impact of different levels of ...
Chiara Roversi +5 more
semanticscholar +1 more source