Results 41 to 50 of about 289,056 (239)

Target organ damage in stress-induced arterial hypertension

open access: yesКардиоваскулярная терапия и профилактика, 2009
Aim. То investigate the features of target organ damage in patients with stress-induced arterial hypertension (AH).Material and methods. The study included 329 men, aged 29—55 years, with Stage I-II AH. Group I consisted of 197 individuals with workplace
O. N. Antropova   +3 more
doaj  

Heart rate variability and target organ damage in hypertensive patients

open access: yesBMC Cardiovascular Disorders, 2012
Background We evaluated the association between linear standard Heart Rate Variability (HRV) measures and vascular, renal and cardiac target organ damage (TOD).
Melillo Paolo   +3 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Relaxin does not improve Angiotensin II-induced target-organ damage.

open access: yesPLoS ONE, 2014
Relaxin is a corpus-luteum produced protein hormone with vasodilatatory, anti-fibrotic, and angiogenic properties that are opposite to angiotensin (Ang) II. We investigated whether or not relaxin ameliorates Ang II-induced target-organ damage.
Nadine Haase   +5 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Connecting Cerebral White Matter Lesions and Hypertensive Target Organ Damage

open access: yesJournal of Aging Research, 2011
Chronic hypertension leads to concomitant remodeling of the cardiac and vascular systems and various organs, especially the brain, kidney, and retina. The brain is an early target of organ damage due to high blood pressure, which is the major modifiable ...
Cristina Sierra   +2 more
doaj   +1 more source

Intrinsic and extrinsic epigenetic age acceleration are associated with hypertensive target organ damage in older African Americans

open access: yesBMC Medical Genomics, 2019
Background Epigenetic age acceleration, a measure of biological aging based on DNA methylation, is associated with cardiovascular mortality. However, little is known about its relationship with hypertensive target organ damage to the heart, kidneys ...
Jennifer A. Smith   +7 more
doaj   +1 more source

Sense of coherence and hypertensive target organ damage

open access: yesPsychiatria Polska, 2019
Cel pracyNadciśnienie tętnicze może być powikłane uszkodzeniami narządowymi (oznaczanymi w języku angielskim skrótem TOD – target organ damage). Do chwili obecnej udało się zidentyfikować wiele różnych czynników powiązanych z rozwojem TOD. Jednak, zgodnie z naszą wiedzą, nie próbowano wyodrębnić zmiennych psychologicznych, które różnicują pacjentów z ...
Lech, Popiołek   +8 more
openaire   +2 more sources

The microbiome in human skin aging

open access: yesFEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana   +3 more
wiley   +1 more source

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