Results 51 to 60 of about 289,056 (239)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Masked Hypertension: Subtypes and Target Organ Damage

Clinical and Experimental Hypertension, 2008
Masked hypertension has been drawing attention recently because this condition is often seen in untreated and treated individuals and is associated with target organ damage and a poor cardiovascular prognosis. Although masked hypertension is defined as normal office blood pressure with elevated ambulatory or home blood pressure, there are several ...
Yuhei, Kawano, Takeshi, Horio, Tetsutaro, Matayoshi, Kei, Kamide   +3 more
openaire   +3 more sources

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Baroreflex deficit are associated with target organ damage

O Mundo da Saúde, 2017
RETRACTED The editorial team of the Journal O Mundo da Saúde communicates the formal retracted the article: PAULINI, Janaina. Baroreflex deficit are associated with target organ damage. Rev. O Mundo da Saúde. 2017;40, n. A: 433-46. https://doi.org/
Janaina Paulini
doaj  

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Serum uric acid and target organ damage in essential hypertension

Vascular Health and Risk Management, 2014
Sandra N Ofori, Osaretin J OdiaDepartment of Internal Medicine, University of Port Harcourt Teaching Hospital, Port Harcourt, Rivers State, NigeriaBackground: Hypertension is a major risk factor for cardiovascular mortality, as it acts through its ...
Ofori SN, Odia OJ
doaj  

Risk reclassification in patients first contacting a doctor with uncomplicated hypertension

Кардиоваскулярная терапия и профилактика, 2019
Aim. To assess the changes of SCORE cardiovascular risk (CVR) in patients with hypertension (HTN) who first seek medical help taking into account target organ damage (TOD).Material and methods.
T. V. Kamyshova, A. A. Sarycheva, V. D. Sargsyan, A. S. Safaryan, D. V. Nebieridze   +4 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

The Strain of Detecting Early Target Organ Damage in Hypertension

Journal of the American College of Cardiology, 2015
Hypertension contributes substantially to the burden of disease in developed nations and, increasingly, in the developing world [(1)][1]. Although recognition of high blood pressure (BP) seems simple, 20% to 30% of individuals have undiagnosed hypertension [(2)][2], and 50% to 70% of ...
Marwick, Thomas H., Venn, Alison J.
openaire   +2 more sources

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source