Results 71 to 80 of about 289,056 (239)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Subtypes of masked hypertension and target organ damage in untreated outpatients

Blood Pressure, 2020
Purpose: Masked hypertension (MHT) is characterised as an office normotension in the presence of out-of-office hypertension, and can be further categorised as isolated daytime (dMHT), night-time (nMHT) or day-night MHT (dnMHT) according to the time when ...
Dong-Yan Zhang, Yi-Bang Cheng, Qian-Hui Guo, Ying Wang, Chang-Sheng Sheng, Qi-Fang Huang, De-Wei An, Ming-Xuan Li, Jian-Feng Huang, Ting-Yan Xu, Ji-Guang Wang, Yan Li   +11 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

P115 ALBUMIN-TO-CREATININE RATIO IS ASSOCIATED WITH TARGET ORGAN DAMAGE IN HYPERTENSION

Artery Research, 2017
Purpose/Background/Objectives: Hypertension is associated with higher cardiovascular risk as well as several markers of subclinical target organ damage (TOD).
Losif Koutagiar, Charalambos Vlachopoulos, Dimitrios Terentes-Printzios, Nikolaos Loakeimidis, Christos Georgakopoulos, Konstantinos Aznaouridis, Panagiotis Xaplanteris, Athanasios Angelis, Dimitrios Tousoulis   +8 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Study on Related Factors Between Essential Hypertension and Target Organ Damage

Huli yanjiu, 2001
To probe into the relationship between the pattern of blood pressure going up and the damage of the target organ heart, brain and kidney, 164 cases of essential hypertension （EH） were monitored with noninvasive ambulant blood pressure monitoring （ABPM ...
张学禹, 胡建红, 郭士英, 高明兰, 王敬萍, 薛树仁, 孔梅   +6 more
doaj  

Comprehensive assessment and management of hypertension in elderly patients: Addressing frailty and target organ damage

Journal of the Formosan Medical Association
The lifetime risk of incident hypertension is approximately 90%. Hypertension is the most important cardiovascular risk factor, and is readily modifiable.
Tzu-Chieh Lin, Ye-Hsu Lu, Chia-Ter Chao, Shin-Jing Lin, Po-Sheng Wu, Ding-Cheng Chan, Hsiang-Chun Lee   +6 more
doaj   +1 more source

Interrelations Between Arterial Stiffness, Target Organ Damage, and Cardiovascular Disease Outcomes

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Excess transmission of pressure pulsatility caused by increased arterial stiffness may incur microcirculatory damage in end organs (target organ damage [TOD]) and, in turn, elevate risk for cardiovascular disease (CVD) events.
Ramachandran S. Vasan, Meghan I. Short, Teemu J. Niiranen, Vanessa Xanthakis, Charles DeCarli, Susan Cheng, Sudha Seshadri, Gary F. Mitchell   +7 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source