Results 91 to 100 of about 545,656 (315)

Bridging Pharmaceutical Chemistry with Drug and Nanoparticle Targeting to Investigate the Role of the 18‐kDa Translocator Protein TSPO [PDF]

, 2017
Rosa Maria Iacobazzi, Antonio Lopalco, Annalisa Cutrignelli, Valentino Laquintana, Angela Lopedota, Massimo Franco, Nunzio Denora   +6 more
openalex   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Hit-optimization using target-directed dynamic combinatorial chemistry: development of inhibitors of the anti-infective target 1-deoxy- d -xylulose-5-phosphate synthase

, 2021
Ravindra P. Jumde, Melissa Guardigni, Robin M. Gierse, Alaa Alhayek, Di Zhu, Rawia Hamid, Sandra Johannsen, Walid A. M. Elgaher, Philipp J. Neusens, Christian Nehls, Jörg Haupenthal, Norbert Reiling, Anna K. H. Hirsch   +12 more
openalex   +2 more sources

Nanomedicine in chemistry education: Targeted drug delivery with polymer nanoparticles [PDF]

, 2023
Antonia Fruntke, Mira Behnke, Elisabeth Dietel, Antje Vollrath, Ulrich S. Schubert, Timm Wilke   +5 more
openalex   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

De novo generation of multi-target compounds using deep generative chemistry

Nature Communications
Polypharmacology drugs—compounds that inhibit multiple proteins—have many applications but are difficult to design. To address this challenge we have developed POLYGON, an approach to polypharmacology based on generative reinforcement learning.
Brenton P. Munson, Michael Chen, Audrey Bogosian, Jason F. Kreisberg, Katherine Licon, Ruben Abagyan, Brent M. Kuenzi, Trey Ideker   +7 more
doaj   +1 more source

Medicinal Chemistry: From Targets to Therapies [PDF]

ACS Medicinal Chemistry Letters, 2019
Bruce E. Maryanoff, Peter Wipf
openaire   +2 more sources

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Medicinal chemistry of P2 and adenosine receptors: Common scaffolds adapted for multiple targets

, 2020
Kenneth A. Jacobson, Adriaan P. IJzerman, Christa E. Müller   +2 more
openalex   +2 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source