Results 41 to 50 of about 534,578 (304)
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Advances in Civil Engineering, 2018 Building energy conservation measure (ECM) of insulation materials suitable for the domestic situation in the construction sector (passive) is established. The ECMs of insulation materials were classified into walls, roofs, and floors.
Bo-Eun Choi +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Linking Burglary and Target Hardening at the Property Level: New Insights Into Victimization and Burglary Protection [PDF]
, 2010 This article draws on a recent study that examined the impact of target hardening on domestic burglary in the City of Liverpool, England, between July 2005 and December 2007. Individual property-level data, from a range of sources, were collated for each
Hirschfield, A +6 more
core +1 more source
Cost analysis for the implementation of LUCF mitigation toward NDC target in Indonesia
Carbon Balance and ManagementBackground The government of Indonesia, as a party to the UNFCCC, has committed to reducing its emissions unconditionally by 31% and conditionally up to 43% from the Business as Usual (BAU) level.
Annuri Rossita, Rizaldi Boer
doaj +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
A Classifier-based target cost for unit selection speech synthesis trained on perceptual data [PDF]
, 2010 Our goal is to automatically learn a PERCEPTUALLY-optimal target cost function for a unit selection speech synthesiser. The approach we take here is to train a classifier on human perceptual judgements of synthetic speech. The output of the classifier is
King, Simon +2 more
core
PLoS ONE, 2017 Target agents are peculiar oncological drugs which differ from the traditional therapies in their ability of recognizing specific molecules expressed by tumor cells and microenvironment.
Francesca Tartari +2 more
doaj +1 more source