Results 41 to 50 of about 523,848 (256)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Cost analysis for the implementation of LUCF mitigation toward NDC target in Indonesia
Carbon Balance and ManagementBackground The government of Indonesia, as a party to the UNFCCC, has committed to reducing its emissions unconditionally by 31% and conditionally up to 43% from the Business as Usual (BAU) level.
Annuri Rossita, Rizaldi Boer
doaj +1 more source
Advances in Civil Engineering, 2018 Building energy conservation measure (ECM) of insulation materials suitable for the domestic situation in the construction sector (passive) is established. The ECMs of insulation materials were classified into walls, roofs, and floors.
Bo-Eun Choi +5 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
PLoS ONE, 2017 Target agents are peculiar oncological drugs which differ from the traditional therapies in their ability of recognizing specific molecules expressed by tumor cells and microenvironment.
Francesca Tartari +2 more
doaj +1 more source
Western Journal of Emergency Medicine, 2016 Introduction: Attending physician judgment is the traditional standard of care for emergency department (ED) admission decisions. The extent to which variability in admission decisions affect cost and quality is not well understood.
Jeffrey J. Guterman +6 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Exploring the impact of compound retrieval strategy in the task-switching paradigm
Frontiers in Human NeuroscienceIntroductionTask-switching costs are commonly used to measure cognitive control. However, previous research has shown that when participants are not explicitly instructed on task rules, they can adopt the compound retrieval strategy in task-switching ...
Fangyuan Zhou, Fangyuan Zhou
doaj +1 more source