Results 51 to 60 of about 534,578 (304)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Exploring the impact of compound retrieval strategy in the task-switching paradigm

open access: yesFrontiers in Human Neuroscience
IntroductionTask-switching costs are commonly used to measure cognitive control. However, previous research has shown that when participants are not explicitly instructed on task rules, they can adopt the compound retrieval strategy in task-switching ...
Fangyuan Zhou, Fangyuan Zhou
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

The Target Opportunity Costs of Successful Nudges

open access: yes, 2020
Nudges are increasingly popular, in large part due to the typically low costs required to implement them. Yet most often the main cost of nudging is due not to their implementation, but rather to the opportunity costs of its successful change of the ...
Avishalom Tor, Tor, Avishalom
core   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

Wide Variability in Emergency Physician Admission Rates: A Target to Reduce Costs Without Compromising Quality

open access: yesWestern Journal of Emergency Medicine, 2016
Introduction: Attending physician judgment is the traditional standard of care for emergency department (ED) admission decisions. The extent to which variability in admission decisions affect cost and quality is not well understood.
Jeffrey J. Guterman   +6 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Renewable Energy Target review [PDF]

open access: yes, 2014
SUMMARY This is the Climate Change Authority\u27s second review of the Renewable Energy Target (RET). The RET targets reductions in greenhouse gas emissions from the electricity sector and thereby contributes significantly to reducing Australia\u27s ...
Climate Change Authority
core  

Estimating costs using a target costing method

open access: yes, 2021
Nowadays, it is not possible for a manufacturer to start designing and manufacturing a new product without accurately estimating its total production costs.
Więcek, Dorota, Kaczmar-Kolny, Ewa
core   +1 more source

A Study on GHG Abatement Costs in Korea: International Emissions Trading and Major Sectors of Carbon Reduction

open access: yesEast Asian Economic Review, 2010
In this paper, we estimate the cost of the GHG abatement target by Korean government using a trade-based model, GTAP-E, after updating all the database of industrial and trade structures as well as carbon dioxide emissions of most of regions of the world.
Chang-Soo Lee , Nam-Yil Kim
doaj   +1 more source

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