Results 51 to 60 of about 2,123,261 (297)

Cost analysis for the implementation of LUCF mitigation toward NDC target in Indonesia

Carbon Balance and Management
Background The government of Indonesia, as a party to the UNFCCC, has committed to reducing its emissions unconditionally by 31% and conditionally up to 43% from the Business as Usual (BAU) level.
Annuri Rossita, Rizaldi Boer
doaj   +1 more source

Target costing in construction: a comparative study [PDF]

, 2014
Target costing is an approach for the development of new products in the automobile industry, aimed at reducing their life-cycle costs while ensuring quality, reliability and other client requirements, by examining all possible ideas for cost reduction ...
Amit Kaushik, Ariovaldo Denis Granja, Kaushal Keraminiyage, Lauri Koskela, Patricia Tzortzopoulos, Reymard Savio, Sampaio Melo   +6 more
core  

Theories of anterior cingulate cortex function : opportunity cost

, 2013
The target article highlights the role of the anterior cingulate cortex (ACC) in conflict monitoring, but ACC function may be better understood in terms of the hierarchical organization of behavior.
Holroyd, Clay
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Assessing the relationship between toxicity and economic cost of oncological target agents: A systematic review of clinical trials.

PLoS ONE, 2017
Target agents are peculiar oncological drugs which differ from the traditional therapies in their ability of recognizing specific molecules expressed by tumor cells and microenvironment.
Francesca Tartari, Alessandro Conti, Roy Cerqueti   +2 more
doaj   +1 more source

Wide Variability in Emergency Physician Admission Rates: A Target to Reduce Costs Without Compromising Quality

Western Journal of Emergency Medicine, 2016
Introduction: Attending physician judgment is the traditional standard of care for emergency department (ED) admission decisions. The extent to which variability in admission decisions affect cost and quality is not well understood.
Jeffrey J. Guterman, Scott R. Lundberg, Geoffrey P. Scheib, Sandra G. Gross-Schulman, Mark J. Richman, Chien-Ju Wang, David A. Talan   +6 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Exploring the impact of compound retrieval strategy in the task-switching paradigm

Frontiers in Human Neuroscience
IntroductionTask-switching costs are commonly used to measure cognitive control. However, previous research has shown that when participants are not explicitly instructed on task rules, they can adopt the compound retrieval strategy in task-switching ...
Fangyuan Zhou, Fangyuan Zhou
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source