Comprehensive chemical proteomics for target deconvolution of the redox active drug auranofin [PDF]
Redox Biology, 2020 Chemical proteomics encompasses novel drug target deconvolution methods in which compound modification is not required. Herein we use Thermal Proteome Profiling, Functional Identification of Target by Expression Proteomics and multiplexed redox ...
Amir Ata Saei +8 more
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Chemoproteomics, A Broad Avenue to Target Deconvolution [PDF]
Advanced ScienceAs a vital project of forward chemical genetic research, target deconvolution aims to identify the molecular targets of an active hit compound.
Yihui Gao +3 more
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Bio-Protocol, 2022 Chemical proteomics focuses on the drug–target–phenotype relationship for target deconvolution and elucidation of the mechanism of action—key and bottleneck in drug development and repurposing.
Xuepei Zhang +4 more
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Chemoproteomic target deconvolution reveals Histone Deacetylases as targets of (R)-lipoic acid [PDF]
Nature Communications, 2023 Lipoic acid is an essential enzyme cofactor in central metabolic pathways. Due to its claimed antioxidant properties, racemic (R/S)-lipoic acid is used as a food supplement but is also investigated as a pharmaceutical in over 180 clinical trials covering
Severin Lechner +10 more
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Accelerating target deconvolution for therapeutic antibody candidates using highly parallelized genome editing [PDF]
Nature Communications, 2021 Efficient deconvolution of antibody targets is needed for phenotype-based discovery. Here, the authors investigate a deconvolution approach based on pooled CRISPR Cas9 to achieve 97% deconvolution success rate.
Jenny Mattsson +9 more
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A novel approach for target deconvolution from phenotype-based screening using knowledge graph [PDF]
Scientific ReportsDeconvoluting drug targets is crucial in modern drug development, yet both traditional and artificial intelligence (AI)-driven methods face challenges in terms of completeness, accuracy, and efficiency. Identifying drug targets, especially within complex
Xiaohong Wang +8 more
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Beyond Pleiotropy: A Call for Target Deconvolution and Chemopreventive Repositioning of Alkaloids in CRC [Letter] [PDF]
Drug Design, Development and TherapyZhenru Wang,1 Xiaochan Tan21Zhejiang Chinese Medical University, Hangzhou, People’s Republic of China; 2The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, People ...
Wang Z, Tan X
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Target deconvolution with matrix-augmented pooling strategy reveals cell-specific drug-protein interactions [PDF]
Cell Chemical Biology, 2023 Ruijun Tian +2 more
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A nonparametric statistical method for deconvolving densities in the analysis of proteomic data [PDF]
BMC BioinformaticsBackground Genomic or proteomic data are frequently affected by noise or are convolutions of different biological signals. This is, e.g., particularly relevant in skin aging research, in which intrinsic aging, driven by genetic factors, and extrinsic ...
Akin Anarat +2 more
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Frontiers in Molecular Biosciences, 2022 Knowing that the drug candidate binds to its intended target is a vital part of drug discovery. Thus, several labeled and label-free methods have been developed to study target engagement.
Tuomas Aleksi Tolvanen +1 more
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