Results 21 to 30 of about 2,749,023 (281)

Deciphering the enzymatic target of a new family of antischistosomal agents bearing a quinazoline scaffold using complementary computational tools

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
A previous phenotypic screening campaign led to the identification of a quinazoline derivative with promising in vitro activity against Schistosoma mansoni. Follow-up studies of the antischistosomal potential of this candidate are presented here.
Victor Sebastian-Perez, Alfonso García-Rubia, Sayed H. Seif el-Din, Abdel-Nasser A. Sabra, Naglaa M. El-Lakkany, Samia William, Tom L. Blundell, Louis Maes, Ana Martinez, Nuria E. Campillo, Sanaa S. Botros, Carmen Gil   +11 more
doaj   +1 more source

Target deconvolution techniques in modern phenotypic profiling. [PDF]

Curr Opin Chem Biol, 2013
The past decade has seen rapid growth in the use of diverse compound libraries in classical phenotypic screens to identify modulators of a given process. The subsequent process of identifying the molecular targets of active hits, also called 'target deconvolution', is an essential step for understanding compound mechanism of action and for using the ...
Lee J, Bogyo M.
europepmc   +4 more sources

Chemoproteomic target deconvolution of lipoic acid reveals Histone Deacetylases as the main targets

, 2022
Abstract Lipoic acid is an essential enzyme cofactor in central metabolic pathways. Due to its claimed antioxidant properties, racemic (R/S)-lipoic acid is used as a food supplement, but is also investigated as a pharmaceutical in over 180 clinical trials covering a broad range of diseases.
Kuster B, Lechner S, Steimbach R, Wang L, Matthias P, Miller A, Medard G.   +6 more
europepmc   +2 more sources

Variational semi-blind sparse deconvolution with orthogonal kernel bases and its application to MRFM [PDF]

, 2014
We present a variational Bayesian method of joint image reconstruction and point spread function (PSF) estimation when the PSF of the imaging device is only partially known.
Se Un Parka, Hero, Alfred O., Park, Se Un, Dobigeon, Nicolas, Alfred O. Heroa, Nicolas Dobigeonb   +5 more
core   +1 more source

Targeted protein degradation reveals BET bromodomains as the cellular target of Hedgehog pathway inhibitor-1

Nature Communications, 2023
Target deconvolution of small molecule hits from phenotypic screens presents a major challenge. Many screens have been conducted to find inhibitors for the Hedgehog signaling pathway – a developmental pathway with many implications in health and disease –
Meropi Bagka, Hyeonyi Choi, Margaux Héritier, Hanna Schwaemmle, Quentin T. L. Pasquer, Simon M. G. Braun, Leonardo Scapozza, Yibo Wu, Sascha Hoogendoorn   +8 more
doaj   +1 more source

Passive Array-Invariant-Based Localization for a Small Horizontal Array Using Two-Dimensional Deconvolution

Applied Sciences, 2022
Recently, the array-invariant method was proposed to passively localize sources of opportunity in shallow water. It exploits multiple arrivals which are different in terms of beam angle and travel time. Conventional plane-wave beamforming in the existing
Yujie Wang, Cheng Chi, Yu Li, Donghao Ju, Haining Huang   +4 more
doaj   +1 more source

Blind deconvolution of sparse pulse sequences under a minimum distance constraint: a partially collapsed Gibbs sampler method [PDF]

, 2012
For blind deconvolution of an unknown sparse sequence convolved with an unknown pulse, a powerful Bayesian method employs the Gibbs sampler in combination with a Bernoulli–Gaussian prior modeling sparsity.
Kail, Georg, Hlawatsch, Franz, Dobigeon, Nicolas, Tourneret, Jean-Yves   +3 more
core   +1 more source

Deconvolution of hemodynamic responses along the cortical surface using personalized functional near infrared spectroscopy

Scientific Reports, 2021
In functional near infrared spectroscopy (fNIRS), deconvolution analysis of oxy and deoxy-hemoglobin concentration changes allows estimating specific hemodynamic response functions (HRF) elicited by neuronal activity, taking advantage of the fNIRS ...
A Machado, Z Cai, T Vincent, G Pellegrino, J-M Lina, E Kobayashi, C Grova   +6 more
doaj   +1 more source

aarjas/Hierarchical-deconvolution: Hierarchical deconvolution codes

, 2022
<p>This repository contains the deconvolution codes from the article</p> <p>Snizhana Ross, Arttu Arjas, Ilkka I Virtanen, Mikko J Sillanpää, Lassi Roininen, Andreas Hauptmann: Hierarchical Deconvolution for Incoherent Scatter Radar Data,
aarjas
core   +1 more source

Investigating Monoliths (Vinyl Azlactone-co-Ethylene Dimethacrylate) as a Support for Enzymes and Drugs, for Proteomics and Drug-Target Studies

Frontiers in Chemistry, 2019
Prior to mass spectrometry, on-line sample preparation can be beneficial to reduce manual steps, increase speed, and enable analysis of limited sample amounts.
Christine Olsen, Frøydis Sved Skottvoll, Ole Kristian Brandtzaeg, Christian Schnaars, Pål Rongved, Elsa Lundanes, Steven Ray Wilson   +6 more
doaj   +1 more source