Results 81 to 90 of about 1,532,764 (266)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Offshore Ship Detection in Foggy Weather Based on Improved YOLOv8

Journal of Marine Science and Engineering
The detection and surveillance of ship targets in coastal waters is not only a crucial technology for the advancement of ship intelligence, but also holds great significance for the safety and economic development of coastal areas.
Shirui Liang, Xiuwen Liu, Zaifei Yang, Mingchen Liu, Yong Yin   +4 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Dim Target Detection in Infrared Images Using Saliency Algorithms [PDF]

Radioengineering, 2019
Infrared (IR) target detection and tracking are commonly used in modern defense systems. Target detection is the first and very important step for several surveillance applications.
S. Tunc, H. A. Ilgin
doaj  

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

RESRTDETR: Cross-Scale Feature Enhancement Based on Reparameterized Convolution and Channel Modulation

IEEE Access
This paper proposes an innovative approach for detecting defects in insulators of overhead transmission lines. It employs a real-time object detector (RT-DETR) model named RESRTDETR to address the challenges faced by traditional methods in multi-object ...
Chen Xi, Cui Rongbin, Jiang Yufan, Yao Fulong, Zhang Yingming, Chunhe Song   +5 more
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Vehicle Multi-Object Detection and Tracking Algorithm Based on Improved You Only Look Once 5s Version and DeepSORT

Applied Sciences
The increasing popularity of vehicles has led to traffic congestion and frequent traffic accidents. Intelligent transportation technology is an effective solution to this problem.
Thioanh Bui, Guihao Wang, Geng Wei, Qian Zeng   +3 more
doaj   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source