Results 161 to 170 of about 1,671,904 (310)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Learning Unsupervised Cross-Domain Model for TIR Target Tracking [PDF]

The limited availability of thermal infrared (TIR) training samples leads to suboptimal target representation by convolutional feature extraction networks, which adversely impacts the accuracy of TIR target tracking methods.
Xiu Shu, Feng Huang, Di Yuan, Zhaobing Qiu, Xinming Zhang   +4 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Domain Knowledge Decomposition for Cross-Domain Few-Shot Scene Classification From Remote Sensing Imagery

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Cross-domain few-shot scene classification (CDFSSC) aims to tackle the challenge of classifying target domain data with limited labeled samples under distribution shift and category mismatch in remote sensing (RS) imagery classification. Existing methods
Can Li, He Chen, Yin Zhuang, Liang Chen, Lianlin Li   +4 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Classroom practice for understanding pointers using learning support system for visualizing memory image and target domain world. [PDF]

Res Pract Technol Enhanc Learn, 2017
Yamashita K, Fujioka R, Kogure S, Noguchi Y, Konishi T, Itoh Y.   +5 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

TO-UGDA: target-oriented unsupervised graph domain adaptation

Scientific Reports
Graph domain adaptation (GDA) aims to address the challenge of limited label data in the target graph domain. Existing methods such as UDAGCN, GRADE, DEAL, and COCO for different-level (node-level, graph-level) adaptation tasks exhibit variations in ...
Zhuo Zeng, Jianyu Xie, Zhijie Yang, Tengfei Ma, Duanbing Chen   +4 more
doaj   +1 more source

Domain adaptation for cross-domain alignment in human activity recognition using device-free sensing [PDF]

Over the past years, Wireless-Fidelity (Wi-Fi) sensor-oriented system networks have gained significant attention for conveying information via radio data transmission due to their ease of deployment on a large scale and high throughput yield.
Hassan, Muhammad
core   +1 more source