Results 111 to 120 of about 4,123,279 (296)
Community engagement overview. [PDF]
, 2017 This pathway covers community engagement to improve people's health. This involves 4 important, interlocking themes: prerequisites for success (including policy development); infrastructure (to support practice on the ground); approaches (to support and ...
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Civic Learning/Student Engagement Subcommittee Report
, 2003 University of Minnesota: Civic Learning/Student Engagement Subcommittee. (2003). Civic Learning/Student Engagement Subcommittee Report.
University of Minnesota: Civic Learning/Student Engagement Subcommittee
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Target engagement of biguanides in colorectal carcinoma
Discover ChemistryColorectal cancer (CRC) continues to be the largest reason for disease-related illnesses and fatalities globally, emphasizing the critical necessity finding new along with affordable therapy approaches.
Poulami Patra +2 more
doaj +1 more source
Office for Public Engagement: Task Force on Faculty Scholarship, Development and Rewards
, 2008 University of Minnesota: Office for Public Engagement. (2008). Office for Public Engagement: Task Force on Faculty Scholarship, Development and Rewards.
University of Minnesota: Office for Public Engagement
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
SLAS DiscoveryDrug discovery for challenging drug targets necessitates the proteomic complexities of the cellular milieu for contextual target folding and function.
Ivan Babic +5 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source