Results 91 to 100 of about 4,123,279 (296)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Civic Engagement Awardee's List 2001-2002

, 2001
University of Minnesota: Office for Public Engagement. (2001). Civic Engagement Awardee's List 2001-2002.
University of Minnesota: Office for Public Engagement
core  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Cardiolipin remodelling in mitochondrial therapeutics: translational evidence chains from elamipretide to emerging strategies

Frontiers in Physiology
Mitochondrial therapeutics have repeatedly fallen short of disease modification, in part because inner-membrane architecture constrains both molecular access and the reversibility of bioenergetic failure.
Ke Di, Yusheng Hu, Hechen Sun, Tianwei Meng, Tingquan Han, Tingquan Han, Rui Qie   +6 more
doaj   +1 more source

Office for Public Engagement: Accounting and Assessment Task Force

, 2008
University of Minnesota: Office for Public Engagement. (2008). Office for Public Engagement: Accounting and Assessment Task Force.
University of Minnesota: Office for Public Engagement
core  

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Experimental assessment of computationally nominated small molecules targeting the YAP–TEAD interface in Hippo pathway-altered mesothelioma cell models

Frontiers in Oncology
Aberrant activation of the Hippo–YAP/TAZ–TEAD transcriptional axis is a recurrent feature of multiple solid tumors and contributes to tumor maintenance, lineage plasticity, and therapeutic resistance.
Glen J. Weiss, Glen J. Weiss, Joseph C. Loftus, David W. Mallery, Nhan L. Tran, Nhan L. Tran   +5 more
doaj   +1 more source

COPE Subcommittee on Civic Learning and Student Engagement Report

, 2002
University of Minnesota: Council on Public Engagement. (2002). COPE Subcommittee on Civic Learning and Student Engagement Report.
University of Minnesota: Council on Public Engagement
core  

Comparing two work-engagement scales: Relationships with job satisfaction, organizational commitment, and workaholism [PDF]

, 2013
Although research on work engagement has made great progress over the past 10 years, how best to measure work engagement is still an open question. The aim of the present study was to compare two multidimensional scales measuring work engagement: the ...
Stoeber, Joachim, Davis, Charlotte R., Townley, Jessica   +2 more
core  

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source