Results 141 to 150 of about 321,890 (254)

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Potent Fluorescent Probe for Target-Engagement Studies of Allosteric Pyruvate Kinase Modulators. [PDF]

Angew Chem Int Ed Engl
Nilsson O, Valaka AP, Håversen L, Bogucka A, Köteles I, Brear P, Rutberg M, Gunnarsson A, Hyvönen M, Grøtli M.   +9 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Self‐Regulated Learning Meets AI: Reinterpreting Self‐Regulation, Co‐Regulation, and Socially Shared Regulation in Human–AI Interaction

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley   +1 more source

BPTF Target Engagement by Acetylated H2A.Z Photoaffinity Probes. [PDF]

Biochemistry
Peterson KE, Olson NM, Dahlseid DJ, Artymiuk JM, Erber L, Vitorino FNL, Dean R, Landry JW, Tretyakova NY, Garcia BA, Pomerantz WCK.   +10 more
europepmc   +1 more source

Community engagement SMART targets

For this deliverable we will identify SMART (specific, measurable, achievable, time-bound) targets which the project should realise for effective engagement with both frontline communities and consumers of the eventual information. These targets will effectively stage the balance between data generation, processing and working with NGO networks to ...
openaire   +1 more source

Vestibular Patient Journey: Insights From Vestibular Disorders Association (VeDA) Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Vestibular symptoms impose a high burden of disability. Understanding real‐world diagnostic and treatment pathways can identify care gaps and guide interventions. We aimed to characterize symptom profiles, diagnostic trends, provider involvement, and treatment patterns in vestibular disorders.
Ali Rafati, Sami I. Nassar, Shaun A. Nguyen, Patricia L. Gerend, Michael C. Schubert, Michael T. Teixido, Frederick A. Godley, Joel A. Goebel, Cynthia A. Ryan, Habib G. Rizk, Amir Kheradmand   +10 more
wiley   +1 more source

In Vivo Target Engagement Assessment of Nintedanib in a Double-Hit Bleomycin Lung Fibrosis Rat Model. [PDF]

Int J Mol Sci
Pitozzi V, Caruso PL, Pontis S, Pioselli B, Ruscitti F, Pittelli MG, Lagrasta CAM, Quaini F, Nogara AM, Aquino G, Volta R, Faietti ML, Bonatti M, Spagnolo P, Trevisani M.   +14 more
europepmc   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

A conserved PIWI silencing complex detects piRNA-target engagement. [PDF]

Mol Cell
De D, Sarkar S, Gebert LFR, Wiryaman T, Anzelon TA, MacRae IJ.   +5 more
europepmc   +1 more source