Results 161 to 170 of about 4,123,279 (296)

Target engagement in SNT as measured by interleaved TMS-fMRI

Brain Stimulation, 2023
Martin Tik, John Philip Coetzee, Nimrod Yaakov Keynan, Noriah Daria Johnson, Andrew Dedinas Geoly, Malvika Sridhar, Clive Sahil Veerapal, Saron Atnafu Hunegnaw, Adam Kerr, Nolan Williams   +9 more
doaj   +1 more source

Quantitative Spatial Profiling of Antibody Delivery and Target Engagement Using Optically Labeled Antibodies. [PDF]

J Nucl Med
Tanaka H, Vasiukov G, Grisham CJ, Kazi M, Gowrishankar S, Rosenthal EL.   +5 more
europepmc   +1 more source

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

FEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn, Artur Osyczka, Marcin Sarewicz   +2 more
wiley   +1 more source

In Vivo Efficacy and Biochemical Target Engagement of a Chromene-Based Inhibitor of Trypanosoma cruzi Lysyl-tRNA Synthetase. [PDF]

J Med Chem
Dos Santos TCF, de Lima Silva CC, Eufrásio AG, Tambascia C, De Sousa IL, Marchese L, Catelli MF, de Almeida LR, Costa Venancio GD, de Souza VB, Schenka AA, Rocco SA, Mercaldi GF, Cordeiro AT.   +13 more
europepmc   +1 more source

TARGETING ON INSTAGRAM: MAXIMIZING ENGAGEMENT AND REACH

This article explores the importance of targeting in Instagram marketing, providing an in-depth guide to help businesses connect with their ideal audiences. It begins by highlighting Instagram's extensive user base and the potential for brands to foster engagement and drive conversions.
openaire   +2 more sources

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

An Innovative Multifaceted Approach to Enhance the Sensitivity of a Target Engagement ELISA. [PDF]

Pharm Res
Qiu N, Nitsche A, Beley I, Maiolica A, Cunliffe J, De Gagné J.   +5 more
europepmc   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Optimization and Characterization of SHIP1 Ligands for Cellular Target Engagement and Activity in Alzheimer's Disease Models. [PDF]

J Med Chem
Jesudason CD, Rangel-Barajas C, Beach CJ, Beck DE, Caballero-Floran IH, Clayton WB, Da Silva L, David JC, Doolen S, Faulkner AN, Hamdani AK, Huhe H, Huynh K, Imhoff RD, Javens-Wolfe J, Mason ER, Moussaif M, Singhal K, Soni DM, van Buuren-Milne M, Williams SP, Angus SP, Chu S, Dage JL, Hipskind PA, Johnson TS, Kaddurah-Daouk R, Lamb BT, Meikle PJ, Mesecar AD, Palkowitz AD, Quinney SK, Sukoff Rizzo SJ, Oblak AL, Richardson TI.   +34 more
europepmc   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source