Results 21 to 30 of about 4,123,279 (296)
Frontiers in Molecular Biosciences, 2022 Knowing that the drug candidate binds to its intended target is a vital part of drug discovery. Thus, several labeled and label-free methods have been developed to study target engagement.
Tuomas Aleksi Tolvanen +1 more
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mAbs, 2020 Tumor necrosis factor (TNF) and interleukin (IL)-17A are pleiotropic cytokines implicated in the pathogenesis of several autoimmune diseases including rheumatoid arthritis (RA) and psoriatic arthritis (PsA).
Songmao Zheng +10 more
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Pharmaceuticals, 2021 Impaired glucocorticoid (GC) signaling is a significant factor in aging, stress, and neurodegenerative diseases such as Alzheimer’s disease. Therefore, the study of GC-mediated stress responses to chronic moderately stressful situations, which occur in ...
Dolors Puigoriol-Illamola +8 more
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Marketing Brexit: investigating young voter engagement with the EU Referendum [PDF]
, 2018 This paper presents a study of young voter engagement in relation to the EU referendum – a democratic vote on the United Kingdom's membership of the European Union. Using the marketing concept of engagement we examine how young voters engaged cognitively,
Harvey, John +10 more
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Cycloguanil and Analogues Potently Target DHFR in Cancer Cells to Elicit Anti-Cancer Activity
Metabolites, 2023 Dihydrofolate reductase (DHFR) is an established anti-cancer drug target whose inhibition disrupts folate metabolism and STAT3-dependent gene expression. Cycloguanil was proposed as a DHFR inhibitor in the 1950s and is the active metabolite of clinically
Jennifer I. Brown +15 more
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Chemo‐proteomics in antimalarial target identification and engagement
Medicinal Research Reviews, 2023 AbstractHumans have lived in tenuous battle with malaria over millennia. Today, while much of the world is free of the disease, areas of South America, Asia, and Africa still wage this war with substantial impacts on their social and economic development. The threat of widespread resistance to all currently available antimalarial therapies continues to
Brodie L. Bailey +3 more
openaire +2 more sources
Thermal proteome profiling in bacteria: probing protein state in vivo
Molecular Systems Biology, 2018 Increasing antibiotic resistance urges for new technologies for studying microbes and antimicrobial mechanism of action. We adapted thermal proteome profiling (TPP) to probe the thermostability of Escherichia coli proteins in vivo. E.
André Mateus +7 more
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Pharmaceutics, 2020 To facilitate the development of broad-spectrum retina neuroprotectants that can be delivered through topical dosage forms, this proteomics study focused on analyzing target engagements through the identification of functional protein networks impacted ...
Laszlo Prokai +3 more
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Examining Student Engagement with Safe Dates [PDF]
, 2022 A growing body of evidence suggests that program implementation is significantly related to the efficacy of child and adolescent prevention programming.
Langley, Nickolas R
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Matlab Class for Rapid Visualization of Missile-Target Engagement Scenarios [PDF]
Problemy Mechatroniki, 2023 In this paper, the authorial Matlab Battlespace Visualization Class (MBVC) is proposed to plan, design, and compose the preliminary version of the desired computer animation, which can then be used both as a background for the discussion of the final ...
Witold BUŻANTOWICZ (witold.buzantowicz@wat.edu.pl)
doaj +1 more source