Results 21 to 30 of about 321,270 (256)
mAbs, 2022 An in-house antibody generation campaign identified a diverse, high affinity set of anti-interleukin-11 (IL-11) monoclonal antibodies (mAbs) to enable successful development of novel, custom ultra-sensitive target engagement assays for detection of “free”
Maria Myzithras +12 more
doaj +1 more source
Acute retigabine‐induced effects on myelinated motor axons in amyotrophic lateral sclerosis
Pharmacology Research & Perspectives, 2022 Altered motor neuron excitability in patients with amyotrophic lateral sclerosis (ALS) has been suggested to be an early pathophysiological mechanism associated with motor neuron death.
Boudewijn T. H. M. Sleutjes +6 more
doaj +1 more source
Molecules, 2021 Chemical biology and drug discovery are two scientific activities that pursue different goals but complement each other. The former is an interventional science that aims at understanding living systems through the modulation of its molecular components ...
Benoit Deprez +8 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2022 Knowing that the drug candidate binds to its intended target is a vital part of drug discovery. Thus, several labeled and label-free methods have been developed to study target engagement.
Tuomas Aleksi Tolvanen +1 more
doaj +1 more source
Chemo‐proteomics in antimalarial target identification and engagement
Medicinal Research Reviews, 2023 AbstractHumans have lived in tenuous battle with malaria over millennia. Today, while much of the world is free of the disease, areas of South America, Asia, and Africa still wage this war with substantial impacts on their social and economic development. The threat of widespread resistance to all currently available antimalarial therapies continues to
Brodie L. Bailey +3 more
openaire +2 more sources
mAbs, 2020 Tumor necrosis factor (TNF) and interleukin (IL)-17A are pleiotropic cytokines implicated in the pathogenesis of several autoimmune diseases including rheumatoid arthritis (RA) and psoriatic arthritis (PsA).
Songmao Zheng +10 more
doaj +1 more source
Pharmaceuticals, 2021 Impaired glucocorticoid (GC) signaling is a significant factor in aging, stress, and neurodegenerative diseases such as Alzheimer’s disease. Therefore, the study of GC-mediated stress responses to chronic moderately stressful situations, which occur in ...
Dolors Puigoriol-Illamola +8 more
doaj +1 more source
Cycloguanil and Analogues Potently Target DHFR in Cancer Cells to Elicit Anti-Cancer Activity
Metabolites, 2023 Dihydrofolate reductase (DHFR) is an established anti-cancer drug target whose inhibition disrupts folate metabolism and STAT3-dependent gene expression. Cycloguanil was proposed as a DHFR inhibitor in the 1950s and is the active metabolite of clinically
Jennifer I. Brown +15 more
doaj +1 more source
Thermal proteome profiling in bacteria: probing protein state in vivo
Molecular Systems Biology, 2018 Increasing antibiotic resistance urges for new technologies for studying microbes and antimicrobial mechanism of action. We adapted thermal proteome profiling (TPP) to probe the thermostability of Escherichia coli proteins in vivo. E.
André Mateus +7 more
doaj +1 more source
Pharmaceutics, 2020 To facilitate the development of broad-spectrum retina neuroprotectants that can be delivered through topical dosage forms, this proteomics study focused on analyzing target engagements through the identification of functional protein networks impacted ...
Laszlo Prokai +3 more
doaj +1 more source