Results 31 to 40 of about 321,270 (256)
Matlab Class for Rapid Visualization of Missile-Target Engagement Scenarios [PDF]
Problemy Mechatroniki, 2023 In this paper, the authorial Matlab Battlespace Visualization Class (MBVC) is proposed to plan, design, and compose the preliminary version of the desired computer animation, which can then be used both as a background for the discussion of the final ...
Witold BUŻANTOWICZ (witold.buzantowicz@wat.edu.pl)
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Quantification of Trastuzumab–HER2 Engagement In Vitro and In Vivo
Molecules, 2020 Human EGF Receptor 2 (HER2) is an important oncogene driving aggressive metastatic growth in up to 20% of breast cancer tumors. At the same time, it presents a target for passive immunotherapy such as trastuzumab (TZM).
Alena Rudkouskaya +3 more
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A high content, high throughput cellular thermal stability assay for measuring drug-target engagement in living cells. [PDF]
PLoS ONE, 2018 Determining and understanding drug target engagement is critical for drug discovery. This can be challenging within living cells as selective readouts are often unavailable.
Andrew J Massey
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In Situ Target Engagement Studies in Adherent Cells [PDF]
ACS Chemical Biology, 2018 A prerequisite for successful drugs is effective binding of the desired target protein in the complex environment of a living system. Drug-target engagement has typically been difficult to monitor in physiologically relevant models, and with current methods, especially, while maintaining spatial information.
Hanna Axelsson +8 more
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Cell Reports MedicineSummary: Matrix stiffening by lysyl oxidase-like 2 (LOXL2)-mediated collagen cross-linking is proposed as a core feedforward mechanism that promotes fibrogenesis.
Joseph A. Bell +24 more
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mAbs, 2020 Selecting the dose for efficacy and first-in-human studies of bispecific antibodies (BsAbs) is a challenging process. Herein, positron emission tomography (PET) imaging with 89Zr-labeled IBI322, an anti-CD47/PD-L1 BsAb, was used to optimize the safety ...
Yan Wang +13 more
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Frontiers in PharmacologyT-cell engagers (TCEs) represent a promising therapeutic strategy for various cancers and autoimmune disorders. These bispecific antibodies act as bridges, connecting T-cell receptors (TCRs) to target cells (either malignant or autoreactive) via ...
Massimo Lai +5 more
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Articulating ethical principles guiding Target Malaria's engagement strategy
Malaria Journal, 2022 Progress in gene drive research has engendered a lively discussion about community engagement and the ethical standards the work hinges on. While there is broad agreement regarding ethical principles and established best practices for conducting clinical
Aaron J. Roberts, Delphine Thizy
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Resistance to kinase inhibition through shortened target engagement
Molecular & Cellular Oncology, 2022 Imatinib, a selective inhibitor of the breakpoint cluster region (BCR)-ABL kinase, is the poster child for targeted cancer therapeutics. However, its efficacy is limited by resistance mutations.
Aziz M. Rangwala +4 more
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Maximizing brain networks engagement via individualized connectome-wide target search
Brain Stimulation, 2022 Background: In recent years, the possibility to noninvasively interact with the human brain has led to unprecedented diagnostic and therapeutic opportunities.
Arianna Menardi +5 more
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