Results 51 to 60 of about 321,270 (256)
Expect the unexpected? Challenges of prospectively exploring stakeholder engagement in research
Humanities & Social Sciences Communications, 2021 Stakeholder engagement in research is increasingly viewed as making a major contribution to assisting impact. This paper draws on a longitudinal, prospective impact study exploring stakeholder engagement in a 3-year tobacco control research project which
Alison O’Shea +6 more
doaj +1 more source
Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
Attacking COVID-19 Progression Using Multi-Drug Therapy for Synergetic Target Engagement
Biomolecules, 2021 COVID-19 is a devastating respiratory and inflammatory illness caused by a new coronavirus that is rapidly spreading throughout the human population.
Mathew A. Coban +11 more
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The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Beam Bump Method of Target Engagement [PDF]
IEEE Transactions on Nuclear Science, 1965 At the Cambridge Electron Accelerator we have developed a technique of engaging a thin tungsten target, located in a field-free straight section, with a 6 Gev electron beam. A distortion (bump) of the equilibrium orbit of the synchrotron is produced by powering backleg windings on four selected synchrotron magnets in a prescribed way.
openaire +3 more sources
Advanced ScienceTrastuzumab (TZM) is a monoclonal antibody that targets the human epidermal growth factor receptor 2 (HER2) and is clinically used for the treatment of HER2‐positive breast tumors.
Amit Verma +9 more
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Concurrent/Interleaved TMS–fMRI as an MR-Guided Framework for Target Engagement
Applied SciencesConcurrent/interleaved transcranial magnetic stimulation combined with functional MRI (TMS–fMRI) enables causal perturbation of targeted cortical regions while measuring whole-brain MR-based responses during stimulation.
Chiara Di Fazio, Sara Palermo
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Advances in Cellular Target Engagement and Target Deconvolution [PDF]
SLAS Discovery, 2020 Martin J, Main, Andrew X, Zhang
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