Results 61 to 70 of about 4,123,279 (296)
Concurrent/Interleaved TMS–fMRI as an MR-Guided Framework for Target Engagement
Applied SciencesConcurrent/interleaved transcranial magnetic stimulation combined with functional MRI (TMS–fMRI) enables causal perturbation of targeted cortical regions while measuring whole-brain MR-based responses during stimulation.
Chiara Di Fazio, Sara Palermo
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Advances in Cellular Target Engagement and Target Deconvolution [PDF]
SLAS Discovery, 2020 Martin J, Main, Andrew X, Zhang
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Targeting social learning and engagement
Environmental modelling & software, 2020 Serious games and gamification are useful tools for learning and sustaining long-term engagement in the activities that are not meant to be entertaining. However, the application of game design in the participatory modeling context remains fragmented and mostly limited to user-friendly interfaces, storytelling, and visualization for better ...
Bakhanova, Elena +3 more
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Beam Bump Method of Target Engagement [PDF]
IEEE Transactions on Nuclear Science, 1965 At the Cambridge Electron Accelerator we have developed a technique of engaging a thin tungsten target, located in a field-free straight section, with a 6 Gev electron beam. A distortion (bump) of the equilibrium orbit of the synchrotron is produced by powering backleg windings on four selected synchrotron magnets in a prescribed way.
openaire +3 more sources
Frontiers in PharmacologyIntra-Target Microdosing (ITM), integral to Phase 0 clinical studies, offers a novel approach in drug development, effectively bridging the gap between preclinical and clinical phases.
Yasunori Aoki +4 more
doaj +1 more source
Nature Communications, 2020 Chemical tools to monitor drug-target engagement of endogenous enzymes are essential for preclinical target validation. Here, the authors present a chemical genetics strategy to study target engagement of endogenous kinases, achieving specific labeling ...
Tom van der Wel +13 more
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