Results 11 to 20 of about 1,410,269 (267)

Advances in Anthelmintic Target Identification. [PDF]

Int J Mol Sci
Parasitic nematodes pose a significant threat to human and animal health, causing widespread morbidity and substantial socioeconomic losses globally. Despite the utility of anthelmintic drugs in parasite control, the emergence of widespread resistance necessitates the discovery of novel interventions.
Shanley HT, Wang T, Taki AC, Byrne JJ, Chang BCH, Sleebs BE, Gasser RB.   +6 more
europepmc   +3 more sources

Computational identification of microRNAs and their targets [PDF]

Birth Defects Research Part C: Embryo Today: Reviews, 2006
One of the most important advances in biology in recent years may be the discovery of RNAs that can regulate gene expression. As one kind of such functional noncoding RNAs, microRNAs (miRNAs) form a class of endogenous 19-23-nucleotide RNAs that can have important regulatory roles in animals and plants by targeting transcripts for cleavage or ...
Yoon, Sungroh, De Micheli, Giovanni
openaire   +6 more sources

Identification of Desmogleins as Disease Targets [PDF]

Journal of Investigative Dermatology, 2007
While it had long been known that desmosomes were crucial for interconnecting cells in laboratory experiments, the link between desmosomal adhesion and human health was bolstered by several key experiments demonstrating that desmogleins were targeted in both autoimmune and infectious diseases.
Simpson, Cory L., Green, Kathleen J.
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Target identification by image analysis [PDF]

Natural Product Reports, 2016
Biologically active compounds induce phenotypic changes in target cells, which can be used to predict their modes of action. Such changes were initially detected by a visual inspection of images, while recent studies are based on high content analysis (HCA) methods using automated microscopy and analysis software.
Fetz, V., Prochnow, H., Brönstrup, M., Sasse, F.   +3 more
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Identification of a peptide targeting CD56

Immunobiology, 2020
Neural cell adhesion molecule 1 (NCAM1/CD56) is expressed on immune cells, myoblasts, and malignant cells, and there is a growing demand for the genetic detection of CD56 and CD56-targeted therapy. In the present study, we developed a novel peptide ligand (designated Natein) that binds to human CD56 by using T7 phage display technology.
Hongxing, Huang, Ying, Liu, Xiaoming, Ouyang, Hua, Wang, Yan, Zhang   +4 more
openaire   +2 more sources

In-silico guided chemical exploration of KDM4A fragments hits

Clinical Epigenetics, 2023
Background Lysine demethylase enzymes (KDMs) are an emerging class of therapeutic targets, that catalyse the removal of methyl marks from histone lysine residues regulating chromatin structure and gene expression. KDM4A isoform plays an important role in
Jessica Lombino, Rosario Vallone, Maura Cimino, Maria Rita Gulotta, Giada De Simone, Maria Agnese Morando, Raffaele Sabbatella, Simona Di Martino, Mario Fogazza, Federica Sarno, Claudia Coronnello, Maria De Rosa, Chiara Cipollina, Lucia Altucci, Ugo Perricone, Caterina Alfano   +15 more
doaj   +1 more source

The Structural Basis of DL0410, a Novel Multi-Target Candidate Drug for the Treatment of Alzheimer’s Disease

Crystals, 2023
Alzheimer’s disease (AD) is a complicated disease for which there are still no ideal one-target drugs, while multi-target drugs are closer to ideal drugs and will provide new solutions for the clinical treatment of AD.
Ailin Liu, Jun Zhao, Nicholas J. Huls, Matthias Zeller, Lin Wang, Tonglei Li   +5 more
doaj   +1 more source

Identification of Transcriptional Targets of HOXA5 [PDF]

Journal of Biological Chemistry, 2005
The homeobox gene HOXA5 encodes a transcription factor that has been shown to play important roles in embryogenesis, hematopoiesis, and tumorigenesis. In order to decipher downstream signaling pathways of HOXA5, we utilized oligonucleotide microarray analysis to identify genes that are differentially expressed in HOXA5-induced cells compared with ...
Hexin, Chen, Ethel, Rubin, Huiping, Zhang, Seung, Chung, Charles C, Jie, Elizabeth, Garrett, Shyam, Biswal, Saraswati, Sukumar   +7 more
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STING signaling promotes NK cell antitumor immunity and maintains a reservoir of TCF-1+ NK cells

Cell Reports, 2023
Summary: Natural killer (NK) cells are cytotoxic innate lymphocytes that eradicate tumor cells. Inducing durable antitumor immune responses by NK cells represents a major priority of cancer immunotherapy.
Lu Lu, Chao Yang, Xingyue Zhou, Lingling Wu, Xiaochuan Hong, Wenwen Li, Xinran Wang, Yuanqin Yang, Dongqing Cao, Ao Zhang, Wen Di, Liufu Deng   +11 more
doaj   +1 more source

Pharmacogenetics and target identification in diabetes [PDF]

Current Opinion in Genetics & Development, 2018
In diabetes, pharmacogenetics can be used both to identify patient subgroups who will have most benefit and/or least harm from a particularly treatment, and to gain insights into the molecular mechanisms of drug action and disease aetiology. There is increasing evidence that genetic variation alters response to diabetes treatments-both in terms of ...
openaire   +3 more sources