Suprachoroidal and Subretinal Injections of AAV Using Transscleral Microneedles for Retinal Gene Delivery in Nonhuman Primates. [PDF]
, 2020 Retinal gene therapy using adeno-associated viruses (AAVs) is constrained by the mode of viral vector delivery. Intravitreal AAV injections are impeded by the internal limiting membrane barrier, while subretinal injections require invasive surgery and ...
Chung, Sook Hyun +7 more
core
A Micromechanical Parylene Spiral-Tube Sensor and Its Applications of Unpowered Environmental Pressure/Temperature Sensing [PDF]
, 2007 A multi-function micromechanical pressure/temperature sensor incorporating a microfabricated parylene spiral tube is presented. Its visible responses in expression of in situ rotational tube deformation enable unpowered sensing directly from optical ...
Chen, Po-Jui, Tai, Yu-Chong
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Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.This review aims to provide a broad understanding for interdisciplinary researchers in engineering and clinical applications. It addresses the development and control of magnetic actuation systems (MASs) in clinical surgeries and their revolutionary effects in multiple clinical applications.
Yingxin Huo +3 more
wiley +1 more source
Surgical management of glaucoma secondary to idiopathic elevated episcleral venous pressure
Oman Journal of Ophthalmology, 2015 Idiopathic elevated episcleral venous pressure is characterized by dilated episcleral veins and open angle glaucoma. Trabeculectomies in these eyes are often complicated by uveal effusions (intraoperative or postoperative) at nonhypotonous pressures.
Zia Sultan Pradhan +2 more
doaj +1 more source
Systemic hypotension and low perfusion pressure as risk factors for primary open-angle glaucoma progression [PDF]
Клиническая офтальмология, 2023 O.S. Мyakonkaya1, A.S. Sarkisyan1, A.V. Seleznev2, A.V. Kuroyedov3,4, A.Yu. Brezhnev5 1Volgograd Branch of the S. Fyodorov Eye Microsurgery Federal State Institution, Volgograd, Russian Federation 2Ivanovo State Medical Academy, Ivanovo, Russian
O.S. Myakonkaya +4 more
doaj
Microrobotic Catheterization of the Ophthalmic Artery for Targeted Treatment of Retinoblastoma
Advanced Intelligent Systems, EarlyView.A microrobotic platform is presented that allows teleoperated and autonomous navigation of flow‐driven magnetic microcatheters, MagFlow, into the ophthalmic artery for superselective intra‐arterial infusion of chemotherapy to treat retinoblastoma. Extensive benchtop validations with patient‐derived biomimetic phantoms under optical and fluoroscopic ...
Artur Banach +5 more
wiley +1 more source
In vivo imaging of structural, metabolic and functional brain changes in glaucoma
Neural Regeneration Research, 2019 Glaucoma, the world’s leading cause of irreversible blindness, is a condition for which elevated intraocular pressure is currently the only modifiable risk factor. However, the disorder can continue to progress even at reduced intraocular pressure.
Anisha Kasi +2 more
doaj +1 more source
Animal Models and Experimental Medicine, EarlyView.Steroid‐induced ocular hypertension is a useful mouse model for glaucoma, but published work rarely quantifies how route, dose, and schedule shape the intraocular pressure (IOP) time‐course—hindering reproducibility and forcing labs to pilot protocols.
Nicholas Y. Q. Tan +4 more
wiley +1 more source
CXCR3 antagonism of SDF-1(5-67) restores trabecular function and prevents retinal neurodegeneration in a rat model of ocular hypertension. [PDF]
PLoS ONE, 2012 Glaucoma, the most common cause of irreversible blindness, is a neuropathy commonly initiated by pathological ocular hypertension due to unknown mechanisms of trabecular meshwork degeneration.
Alexandre Denoyer +11 more
doaj +1 more source
Research progress in animal models of dry eye disease: Types, mechanisms, and application prospects
Animal Models and Experimental Medicine, EarlyView.Pivotal multifactorial animal models for translational dry eye disease research. Abstract Dry eye disease (DED) is a prevalent and complex multifactorial ocular surface disorder, leading to significant visual discomfort and diminished quality of life.
Jinshen Liu +12 more
wiley +1 more source