Results 51 to 60 of about 36,896 (275)

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Modular Control of PEG‐Poly(2‐Oxazoline) Co‐Assembly Enables Tunable Aggregate Properties for Intraocular Pressure Management

Advanced Healthcare Materials, EarlyView.
A thermo‐responsive poly(2‐oxazoline)‐based injectable formulation is developed to modulate intraocular pressure (IOP) in both normal and hypotonic eyes. By adjusting the PEG content, the aggregation behavior is finely tuned, enabling IOP elevation without long‐term deposition.
Yuji Tanaka, Shohei Morikawa, Shigehito Osawa   +2 more
wiley   +1 more source

Multifocal versus monofocal intraocular lenses after cataract extraction. [PDF]

, 2012
BACKGROUND: Good unaided distance visual acuity is now a realistic expectation following cataract surgery and intraocular lens (IOL) implantation. Near vision, however, still requires additional refractive power, usually in the form of reading glasses ...
Alio, Cillino, Maghraby, Allen, Haaskjold, Harman, Javitt, Javitt, Jusufovic, Kamlesh, Leyland, Nijkamp, Palmer, Percival, Rossetti, Sen, Steinert, Zhao, Alio, Alio, Allen, Cionni, Hayashi, Hayashi, Hayashi, Hayashi, Hida, Huang, Ji, Liang, Maxwell, Ortiz, Richter-Mueksch, Rocha, Shah, Souza, Liekfeld, Walkow, Xu, Zhang, Allen, Ang, Bailey, Desai, Desai, Desai, Gimbel, Glanville, Haaskjold, Higgins, Holladay, Javitt, Kirkham, Knorz, Lang, Legeais, Lindstrom, Riaz, Steinert, Leyland, Leyland   +60 more
core   +2 more sources

Development of a Novel Intraocular-Pressure-Lowering Therapy Targeting ATX

Biological and Pharmaceutical Bulletin, 2019
Elevated intraocular pressure (IOP) is the major cause of glaucoma, which is the second leading cause of blindness. However, current glaucoma treatments cannot completely regulate IOP and progression of glaucoma. Our group recently found that autotaxin (ATX) activity in human aqueous humor (AH) was positively correlated with increased IOP in various ...
Norimichi, Nagano, Megumi, Honjo, Mitsuyasu, Kawaguchi, Hiroshi, Nishimasu, Osamu, Nureki, Kuniyuki, Kano, Junken, Aoki, Toru, Komatsu, Takayoshi, Okabe, Hirotatsu, Kojima, Tetsuo, Nagano, Makoto, Aihara   +11 more
openaire   +3 more sources

Elevation of intraocular pressure in rodents using viral vectors targeting the trabecular meshwork [PDF]

Experimental Eye Research, 2015
Rodents are increasingly being used as glaucoma models to study ocular hypertension, optic neuropathy, and retinopathy. A number of different techniques are used to elevate intraocular pressure in rodent eyes by artificially obstructing the aqueous outflow pathway.
Iok-Hou, Pang, J Cameron, Millar, Abbot F, Clark   +2 more
openaire   +2 more sources

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

Magnetic Resonance Conditional Microinjector

Journal of Imaging, 2018
Glaucoma, one of the leading causes of blindness, has been linked to increases in intraocular pressure. In order to observe and study this effect, proposed is a specialized microinjector and driver that can be used to inject small amounts of liquid into ...
Adam Wineland, Yue Chen, Brian Boland, Kevin Chan, Zion Tse   +4 more
doaj   +1 more source

Current Knowledge and Attitudes Concerning Cost-Effectiveness in Glaucoma Pharmacotherapy: A Glaucoma Specialists Focus Group Study. [PDF]

, 2020
Background:Rising healthcare costs motivate continued cost-reduction efforts. To help lower costs associated with open-angle glaucoma (OAG), a prevalent, progressive disease with substantial direct and indirect costs, clinicians need to understand the ...
Cioffi, George A, Feldman, Robert M, Feldman, Robert M, Liebmann, Jeffrey M, Weinreb, Robert N   +4 more
core  

A double masked randomised 4-week, placebo-controlled study in the USA, Thailand and Taiwan to compare the efficacy of oral valganciclovir and topical 2% ganciclovir in the treatment of cytomegalovirus anterior uveitis: study protocol. [PDF]

, 2019
IntroductionCytomegalovirus (CMV) anterior uveitis is a recognised cause of anterior uveitis in immunocompetent patients and is preventable cause of vision loss.
Acharya, Nisha R, Doan, Thuy A, Gebreegziabher, Elisabeth A, Gonzales, John A, Joye, Ashlin S, Keenan, Jeremy D, Laovirojjanakul, Wipada, Lietman, Thomas M, Lin, Chang-Ping, Porco, Travis C, Rose-Nussbaumer, Jennifer, Seitzman, Gerami D, Somkijrungroj, Thanapong, Takhar, Jaskirat S   +13 more
core   +2 more sources

Toward Wireless Implantable Robotic Systems Driven by Magnetic Field for Personalized Therapy

Advanced Robotics Research, EarlyView.
Robotic materials are playing an increasingly vital role in enabling sensing and actuation at small scales. This perspective highlights recent advances in magnetic materials and magnetically actuated devices for wireless sensing, actuation, and energy harvesting toward implantable robotic systems for closed‐loop therapy.
Yusheng Wang, Ruijian Ge, Xiaoguang Dong
wiley   +1 more source