Results 51 to 60 of about 120,205 (311)

Leveraging language prior for infrared small target detection

Neurocomputing
IRSTD (InfraRed Small Target Detection) detects small targets in infrared blurry backgrounds and is essential for various applications. The detection task is challenging due to the small size of the targets and their sparse distribution in infrared small target datasets. Although existing IRSTD methods and datasets have led to significant advancements,
Pranav Singh Chib, Pravendra Singh
openaire   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

PENCAPAIAN TARGET LEVERAGE MELALUI SPEED OF ADJUSTMENT KARAKTERISTIK PERUSAHAAN

, 2019
This paper aims to determine the effect of company characteristics on target leverage with the relation of the speed of adjustment to target leverage.
Maulana, Yasir, Yusuf, Ayus Ahmad
core   +1 more source

Board Governance Mechanisms and Capital Structure of Saudi Non-Financial Listed Firms: A Dynamic Panel Analysis

SAGE Open, 2023
The dynamic trade-off model emphasizes that random shocks and other constraints may force firms to deviate from their optimum debt ratio. In addition, firms must incur adjustment costs for them to revert to their target level due to market frictions ...
Ayman Hassan Bazhair
doaj   +1 more source

Leveraging Large-Scale Biobanks for Therapeutic Target Discovery

Human Genetics and Genomics Advances
Abstract Large biobanks, including the Million Veteran Program (MVP), the UK Biobank, and FinnGen, provide genetic association results for more than 1,000,000 individuals for hundreds of phenotypes. To select targets for pharmaceutical development, as well as to improve the understanding of existing targets, we ...
Brian R Ferolito, Hesam Dashti, Claudia Giambartolomei, Gina M Peloso, Daniel J Golden, Kai Gravel-Pucillo, Danielle Rasooly, Andrea RVR Horimoto, Rachael Matty, Liam Gaziano, Yi Liu, Ines A Smit, Barbara Zdrazil, Yakov Tsepilov, Lauren Costa, Nicole Kosik, Jennifer E Huffman, Gian Gaetano Tartaglia, Giorgio Bini, Gabriele Proietti, Harris Ioannidis, Fiona Hunter, Gibran Hemani, Adam S Butterworth, Emanuele Di Angelantonio, Claudia Langenberg, Maya Ghoussaini, Andrew R Leach, Katherine P Liao, Scott Damrauer, Luis E Selva, Stacey Whitbourne, Philip S Tsao, Jennifer Moser, Tom Gaunt, Tianxi Cai, John C Whittaker, Million Veteran Program, Juan P Casas, Sumitra Muralidhar, J Michael Gaziano, Kelly Cho, Alexandre C Pereira   +42 more
openaire   +2 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Constant Leverage And Constant Cost Of Capital: A Common Knowledge Half-Truth

Estudios Gerenciales, 2008
A typical approach for valuing finite cash flows is to assume that leverage is constant (usually as target leverage) and the cost of equity, Ke and the Weighted Average Cost of Capital, WACC are also assumed to be constant.
Ignacio Vélez–Pareja
doaj   +1 more source