Results 61 to 70 of about 120,205 (311)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
A simple analytical model for dynamics of time-varying target leverage ratios
, 2012 In this paper we have formulated a simple theoretical model for the dynamics of the time-varying target leverage ratio of a firm under some assumptions based upon empirical observations.
C.F. Lo, C.H. Hui
core +1 more source
Do Firms Adjust Toward a Target Leverage Level? [PDF]
SSRN Electronic Journal, 2006 L'auteure examine les mécanismes d'ajustement de la structure du capital des entreprises qui subissent d'importantes modifications du levier financier. Ces entreprises s'ajustent à des rythmes différents selon que leur ratio d'endettement augmente ou diminue beaucoup.
openaire +2 more sources
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Debt Financing and Financial Flexibility Evidence from Pro-active Leverage Increases [PDF]
Firms that intentionally increase leverage through substantial debt issuances do so primarily as a response to operating needs rather than a desire to make a large equity payout.
David J. Denis, Stephen B. Mckeon
core
Pencapaian Target Leverage Melalui Speed of Adjusment Karakteristik Perusahaan [PDF]
, 2019 This paper aims to determine the effect of company characteristics on target leverage with the relation of the speed of adjustment to target leverage.
Ayus Ahmad Yusuf,, Yasir Maulana,
core
The Impact of Conservative Accounting on the Speed of Leverage Adjustment in Response to Stock Price Crash Risk [PDF]
Journal of Asset Management and FinancingThis study aimed to investigate how companies adjust the speed at which they move toward their target financial leverage in response to stock price crash risk.
Abdullah Khaled Azeez +2 more
doaj +1 more source
Malaysian Management Journal, 2020 Financial leverage decision by firm continues to attract interest from managers, analysts, researchers, scholars as well as policymakers because of its implications for the firm and its stakeholders. This paper investigates how the complexity of business,
Umar Farouk Abdulkarim +3 more
doaj +1 more source
Leveraging Latent Evolutionary Optimization for Targeted Molecule Generation
2024 IEEE Congress on Evolutionary Computation (CEC)Lead optimization is a pivotal task in the drug design phase within the drug discovery lifecycle. The primary objective is to refine the lead compound to meet specific molecular properties for progression to the subsequent phase of development. In this work, we present an innovative approach, Latent Evolutionary Optimization for Molecule Generation ...
Siddartha Reddy +4 more
openaire +2 more sources
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source