Results 71 to 80 of about 120,205 (311)

Firms' Dynamic Adjustment to Target Capital Structures in Transition Economies [PDF]

We study the capital structure dynamics of Central and Eastern European firms in order to get a better understanding of the quantitative and qualitative development of the financial systems in this region.
R.T.A. de Haas, H.M.M. Peeters
core  

Maximizing Ariel's Survey Leverage for Population-Level Studies of Exoplanets

The Open Journal of Astrophysics
ESA's Ariel mission will be uniquely suited to performing population-level studies of exoplanets. Most of these studies consist of quantifying trends between an Ariel-measured quantity, y, and an a priori planetary property, x; for example, atmospheric ...
Nicolas B Cowan, Ben Coull-Neveu
doaj   +1 more source

Artificial Neural Network to Model Managerial Timing Decision: Non-linear Evidence of Deviation from Target Leverage

International Journal of Computational Intelligence Systems, 2019
The current study highlights the utilization of a non-linear model to analyze an important decision-making process in the study of corporate finance where managers are deciding on the capital structure of a firm.
Hafezali Iqbal Hussain, Fakarudin Kamarudin, Hassanudin Mohd Thas Thaker, Milad Abdelnabi Salem   +3 more
doaj   +1 more source

Leveraging dysregulated tumor metabolism for targeting anticancer bacteria

Science Advances
Widespread application of bacterial-based cancer therapy is limited because of the need to increase therapeutic bacteria specificity to the tumor to improve treatment safety and efficacy. Here, we harness the altered tumor metabolism and specifically elevated kynurenine accumulation to target engineered bacteria to the cancer site.
Akeem Santos, Zeneng Wang, Rashmi Bharti, Goutam Dey, Naseer Sangwan, William Baldwin, Ajay Zalavadia, Alex Myers, Olivia G. Huffman, Justin D. Lathia, Stanley L. Hazen, Ofer Reizes, Mohammed Dwidar   +12 more
openaire   +2 more sources

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

A more realistic valuation: APV and WACC with constant book leverage ratio [PDF]

We value a company that targets its capital structure in book-value terms. This capital structure definition provides us with a valuation that lies between those of Modigliani-Miller (fixed debt) and Miles-Ezzell (fixed market-value leverage ratio).
Fernandez, Pablo
core  

Bioactivity-explorer: a web application for interactive visualization and exploration of bioactivity data

Journal of Cheminformatics, 2019
To better leverage the accumulated bioactivity data in the ChEMBL database, we have developed Bioactivity-explorer, a web application for interactive visualization and exploration of the large-scale bioactivity data in ChEMBL.
Lu Liang, Chunfeng Ma, Tengfei Du, Yufei Zhao, Xiaoyong Zhao, Mengmeng Liu, Zhonghua Wang, Jianping Lin   +7 more
doaj   +1 more source

Environmental Reporting and Speed of Adjustment to Target Leverage: Evidence from a Dynamic Regime Switching Model

Organizacija, 2020
Background and Purpose: This study investigates the impact of environmental reporting on speed of adjustment and adjustment costs which is evaluated based on the ability of firms to adjust to target leverage level for non-financial firms listed in the ...
Hussain Hafezali Iqbal, Kot Sebastian, Thaker Hassanudin Mohd Thas, Turner Jason J   +3 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Excess Leverage and Productivity Growth in Emerging Economies: Is There A Threshold Effect? [PDF]

The paper examines the relationship between leverage and growth in a group of emerging central and eastern European countries, who are at different levels of financial market development. We hypothesize a non-linear relationship in that moderate leverage
Roland, Isabelle, Pal, Sarmistha, Coricelli, Fabrizio, Driffield, Nigel   +3 more
core