Results 1 to 10 of about 226,152 (193)
Mechanistic target of rapamycin controls homeostasis of adipogenesis [PDF]
Journal of Lipid Research, 2013 Signaling mediated by the mechanistic target of rapamycin (mTOR) is believed to play a critical and positive role in adipogenesis, based on pharmacological evidence and genetic manipulation of mTOR regulators and targets.
Mee-Sup Yoon +4 more
doaj +3 more sources
The reverse, but coordinated, roles of Tor2 (TORC1) and Tor1 (TORC2) kinases for growth, cell cycle and separase-mediated mitosis in Schizosaccharomyces pombe [PDF]
Open Biology, 2011 Target of rapamycin complexes (TORCs), which are vital for nutrient utilization, contain a catalytic subunit with the phosphatidyl inositol kinase-related kinase (PIKK) motif.
Nobuyasu Ikai +3 more
doaj +1 more source
Recent Advances in the Development of PI3K/mTOR-Based Anticancer Agents: A Mini Review [PDF]
Folia Medica, 2021 Cancer refers to the group of diseases characterized by uncontrolled growth of abnormal cells. It spreads throughout the body which makes this disease one of the huge global threats to mankind.
Ishan Panchal +4 more
doaj +3 more sources
Current Biology, 2002 Yes! One of the earliest observations indicating the therapeutic importance of mTOR involved the immunosuppressive effects of its inhibitor, rapamycin. Indeed, a form of rapamycin (Rapammune®) is on the market for use in organ transplantation. Recently, Phase I clinical trials were completed in which another form of rapamycin (CCI-779) was tested in ...
Dennis, Patrick B., Thomas, George
openaire +1 more source
Conditional U1 gene silencing in Toxoplasma gondii [PDF]
, 2015 The functional characterisation of essential genes in apicomplexan parasites, such as Toxoplasma gondii or Plasmodium falciparum, relies on conditional mutagenesis systems. Here we present a novel strategy based on U1 snRNP-mediated gene silencing.
Blackman, Michael J. +10 more
core +10 more sources
Poultry Science, 2020 : This study was conducted to explore the regulatory role of the target of rapamycin complex 1 (TORC1) signaling pathway in crop milk synthesis in breeding pigeons (Columba livia).
M.J. Chen +5 more
doaj +1 more source
Target of rapamycin is a key player for auxin signaling transduction in Arabidopsis
Frontiers in Plant Science, 2016 Target of rapamycin (TOR), a master sensor for growth factors and nutrition availability in eukaryotic species, is a specific target protein of rapamycin.
Kexuan eDeng +7 more
doaj +1 more source
Rapamycin induces transactivation of the EGFR and increases cell survival. [PDF]
, 2009 The mammalian target of rapamycin (mTOR) signaling network regulates cell growth, proliferation and cell survival. Deregulated activation of this pathway is a common event in diverse human diseases such as cancers, cardiac hypertrophy, vascular ...
Chaturvedi, D +4 more
core +2 more sources
The target of rapamycin (TOR) proteins [PDF]
Proceedings of the National Academy of Sciences, 2001 Rapamycin potently inhibits downstream signaling from the target of rapamycin (TOR) proteins. These evolutionarily conserved protein kinases coordinate the balance between protein synthesis and protein degradation in response to nutrient quality and quantity.
B, Raught, A C, Gingras, N, Sonenberg
openaire +2 more sources
Premature recruitment of oocyte pool and increased mTOR activity in Fmr1 knockout mice and reversal of phenotype with rapamycin. [PDF]
, 2018 While mutations in the fragile X mental retardation-1 (FMR1) gene are associated with varying reproductive outcomes in females, the effects of a complete lack of FMR1 expression are not known.
Ascano, M +5 more
core +2 more sources