Results 1 to 10 of about 174,708,283 (296)
Mammalian target of rapamycin activity is required for expansion of CD34+ hematopoietic progenitor cells [PDF]
Haematologica, 2009 Background The mammalian target of rapamycin is a conserved protein kinase known to regulate protein synthesis, cell size and proliferation. Aberrant regulation of mammalian target of rapamycin activity has been observed in hematopoietic malignancies ...
Christian R. Geest +4 more
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Rheb and mammalian target of rapamycin in mitochondrial homoeostasis [PDF]
Open Biology, 2013 Mitochondrial dysfunction has been associated with various diseases, such as cancer, myopathies, neurodegeneration and obesity. Mitochondrial homoeostasis is achieved by mechanisms that adapt the number of mitochondria to that required for energy ...
Marlous J. Groenewoud +1 more
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Mammalian Target of Rapamycin: A Target for (Lung) Diseases and Aging [PDF]
Annals of the American Thoracic Society, 2016 Abstract The mammalian target of rapamycin (mTOR) signaling pathway has been studied in the context of an impressive number of biological processes and disease states, including major diseases of the lung such as idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease, as well as the rare condition ...
Brian K Kennedy
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Mammalian Target of Rapamycin in Inflammatory Skin Conditions
European Journal of Inflammation, 2014 The conserved serine/threonine kinase mammalian target of rapamycin (mTOR) is a major regulator of survival growth, proliferation and motility, in response to mitogens, energy and nutrient levels.
A. Balato +9 more
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Mammalian Target of Rapamycin Inhibition in Hepatocellular Carcinoma
World Journal of Hepatology, 2014 Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide. It is associated with a poor prognosis and has limited treatment options. Sorafenib, a multi-targeted kinase inhibitor, is the only available systemic agent for treatment of HCC that improves overall survival for patients with advanced stage disease ...
Jennifer Wu
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Recent Advances in the Development of PI3K/mTOR-Based Anticancer Agents: A Mini Review [PDF]
Folia Medica, 2021 Cancer refers to the group of diseases characterized by uncontrolled growth of abnormal cells. It spreads throughout the body which makes this disease one of the huge global threats to mankind.
Ishan Panchal +4 more
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The Complexes of Mammalian Target of Rapamycin [PDF]
Current Protein & Peptide Science, 2010 The mammalian target of rapamycin (mTOR) has attracted substantial attention because of its involvement in a variety of diseases, such as cancer, cardiac hypertrophy, diabetes and obesity. Current knowledge indicates that mTOR functions as two distinct multiprotein complexes, mTORC1 and mTORC2.
Hongyu, Zhou, Shile, Huang
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Iranian Journal of Allergy, Asthma and Immunology, 2020 Mouse model of multiple sclerosis (MS) is used for the inflammatory demyelinating disease. Rapamycin (RAPA) may contribute to the reduction of inflammatory responses to experimental autoimmune encephalomyelitis (EAE).
Soheila Rezapour-Firouzi +4 more
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Targeting the Mammalian Target of Rapamycin in Lung Cancer [PDF]
The American Journal of the Medical Sciences, 2016 Lung cancer is the leading cause of cancer death worldwide. Despite advances in its prevention and management, the prognosis of patients with lung cancer remains poor. Therefore, much attention is being given to factors that contribute to the development of this disease, the mechanisms that drive oncogenesis and tumor progression and the search for ...
Glenn W, Vicary, Jesse, Roman
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Eupafolin ameliorates lipopolysaccharide-induced cardiomyocyte autophagy via PI3K/AKT/mTOR signaling pathway [PDF]
Iranian Journal of Basic Medical Sciences, 2019 Objective(s): Eupafolin, a major active component of Eupatorium perfoliatum L., has anti-inflammatory and anti-oxidant properties. Lipopolysaccharide (LPS) is responsible for myocardial depression.
Yan Gao, Yi Zhang, Yangyang Fan
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