Results 31 to 40 of about 174,708,283 (296)
Tumor Biology, 2017 YM155, a small molecule inhibitor of survivin, has been studied in many tumors. It has been shown that YM155 inhibited oral squamous cell carcinoma through promoting apoptosis and autophagy and inhibiting proliferation.
Kong-Liang Li +9 more
doaj +1 more source
Quantitative phosphoproteomics reveal that mTOR regulates cell growth and proliferation by phosphorylating a functionally diverse set of substrates [PDF]
, 2012 The atypical Ser/Thr kinase target of rapamycin (TOR) is a central controller of cell growth and proliferation. TOR forms two distinct multiprotein complexes, TORC1 and TORC2, which are structurally and functionally conserved from yeast to humans.
Robitaille, Aaron M.
core +1 more source
Function of mTOR complex 1 and 2 in skeletal muscle [PDF]
, 2009 Growth of an organ during development and during adaptation in the adult can be controlled by alterations either in the number or the size of cells. The two mechanisms are fundamentally different and require distinct regulation.
Bentzinger, Conrad Florian
core +1 more source
Case Reports in Oncology, 2015 The mammalian target of rapamycin inhibitors (mTORIs) everolimus and temsirolimus are approved by the US Food and Drug Administration (FDA) for the treatment of various forms of advanced cancer, and the mTORI sirolimus is approved as an immunosuppressive
Timothy F. Meiller +2 more
doaj +1 more source
Alpha‐lipoic acid inhibits lung cancer growth via mTOR‐mediated autophagy inhibition
FEBS Open Bio, 2020 Lung cancer is the leading cause of cancer‐related death, and there remains a need for novel therapies for this malignancy. Here, we examined the effects of alpha‐lipoic acid (LA), a drug used for treating human diabetic complications, on lung cancer ...
Peipei Peng +7 more
doaj +1 more source
Establishment of a structure-activity relationship of the 1H-imidazo[4,5-c]quinoline-based kinase inhibitor NVP-BEZ235 as a lead for African sleeping sickness [PDF]
, 2014 The compound NVP-BEZ235 (1) is a potent inhibitor of human phospoinositide-3-kinases (PI3Ks) and mammalian target of rapamycin (mTOR) that also showed high inhibitory potency against T. brucei cultures. With an eye towards using 1 as a starting point for
Pollastri, Michael P +11 more
core +1 more source
Potential Mechanisms Connecting Purine Metabolism and Cancer Therapy
Frontiers in Immunology, 2018 Unrestricted cell proliferation is a hallmark of cancer. Purines are basic components of nucleotides in cell proliferation, thus impaired purine metabolism is associated with the progression of cancer.
Jie Yin +9 more
doaj +1 more source
Tumor Biology, 2017 Recently, statins have been demonstrated to improve cancer-related mortality or prognosis in patients of various cancers. However, the details of the apoptosis-inducing mechanisms remain unknown.
Daichiro Fujiwara +6 more
doaj +1 more source
Temsirolimus, an Inhibitor of Mammalian Target of Rapamycin [PDF]
Clinical Cancer Research, 2008 Temsirolimus (Torisel, Wyeth Pharmaceuticals) is an inhibitor of mammalian target of rapamycin (mTOR), a molecule implicated in multiple tumor-promoting intracellular signaling pathways. Temsirolimus recently became the first Food and Drug Administration–approved mTOR-targeted agent based on ...
openaire +2 more sources
Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells [PDF]
, 2014 The anti-diabetic drug metformin regulates T-cell responses to immune activation and is proposed to function by regulating the energy-stress-sensing adenosine-monophosphate-activated protein kinase (AMPK).
Benoit Viollet +17 more
core +1 more source