Results 21 to 30 of about 174,708,283 (296)

Sirt1 decreased adipose inflammation by interacting with Akt2 and inhibiting mTOR/S6K1 pathway in mice[S]

Journal of Lipid Research, 2016
Sirtuin type 1 (Sirt1) and protein kinase B (Akt2) are associated with development of obesity and inflammation, but the molecular mechanisms of Sirt1 and Akt2 interaction on adipose inflammation remain unclear.
Zhenjiang Liu, Lu Gan, Guannv Liu, Yizhe Chen, Tianjiao Wu, Fei Feng, Chao Sun   +6 more
doaj   +1 more source

Mammalian target of rapamycin inhibitors, temsirolimus and torin 1, attenuate stemness-associated properties and expression of mesenchymal markers promoted by phorbol-myristate-acetate and oncostatin-M in glioblastoma cells

Tumor Biology, 2017
The phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling pathway is crucial for tumor survival, proliferation, and progression, making it an attractive target for therapeutic intervention.
Goparaju Chandrika, Kumar Natesh, Deepak Ranade, Ashish Chugh, Padma Shastry   +4 more
doaj   +1 more source

Identification of natural inhibitor from Aframomum melegueta targeting survivin and mammalian rapamycin signaling pathway in Kidney Cancer

Informatics in Medicine Unlocked, 2023
Overactivation of survivin and mammalian rapamycin signaling pathway plays an important role in renal carcinogenesis. Recent studies have shown that extract from Aframomum species produces interesting cytotoxic effects against drug resistance cancer ...
Olusola Olalekan Elekofehinti, Precious Ayomide Ajiboro, Moses Orimoloye Akinjiyan, Tolulope Peter Saliu, Folasade Oluwatobiloba Ayodeji, Funmilola Mabel Ojo, Cecilia Oluwamodupe   +6 more
doaj   +1 more source

New insights into the "in vivo" and "in vitro" functions of mammalian TOR complex 2 [PDF]

, 2010
Target of rapamycin (TOR) is the main controller of cell growth and metabolism in response to nutrients, growth factors and the cellular energy status. TOR is a serine/threonine kinase conserved from yeast to mammals and is found in two functionally and
Cybulski, Nadine
core   +1 more source

Leucine regulates α-amylase and trypsin synthesis in dairy calf pancreatic tissue in vitro via the mammalian target of rapamycin signalling pathway

Animal, 2019
Starch digestion in the small intestines of the dairy cow is low, to a large extent, due to a shortage of syntheses of α-amylase. One strategy to improve the situation is to enhance the synthesis of α-amylase.
L. Guo, J.H. Yao, C. Zheng, H.B. Tian, Y.L. Liu, S.M. Liu, C.J. Cai, X.R. Xu, Y.C. Cao   +8 more
doaj   +1 more source

Pharmacological studies of a novel inhibitor of the mammalian target of rapamycin (mTOR) signaling pathway [PDF]

, 2010
The apoptotic mode of cell death (programmed cell death) is an active and defined process that plays an important role in the development of multicellular organisms and in the regulation and maintenance of cell populations in tissues under physiologic ...
Morad, Samy
core   +1 more source

It's All about Timing: The Involvement of Kir4.1 Channel Regulation in Acute Ischemic Stroke Pathology

Frontiers in Cellular Neuroscience, 2018
An acute ischemic stroke is characterized by the presence of a blood clot that limits blood flow to the brain resulting in subsequent neuronal loss.
Meagan Milton, Patrice D. Smith
doaj   +1 more source

Mammalian/mechanistic target of rapamycin (mTOR) complexes in neurodegeneration

Molecular Neurodegeneration, 2021
Novel targets to arrest neurodegeneration in several dementing conditions involving misfolded protein accumulations may be found in the diverse signaling pathways of the Mammalian/mechanistic target of rapamycin (mTOR).
Henry Querfurth, Han-Kyu Lee
doaj   +1 more source

Elucidating the role of DEPTOR in Alzheimer's disease [PDF]

, 2014
This article has been made available through the Brunel Open Access Publishing Fund.The mammalian or mechanistic target of rapamycin (mTOR) is a Ser/Thr protein kinase that, in response to nutrient stimulation, regulates cellular growth, proliferation ...
Karteris, E, Zachariades, E, Rogers-Broadway, K-R, Davies, J   +3 more
core   +5 more sources

Animal amino acid sensor — A review [PDF]

Animal Bioscience
Cell growth and metabolism necessitate the involvement of amino acids, which are sensed and integrated by the mammalian target of rapamycin complex 1 (mTORC1).
Yongding Ke, Xinyu Peng, Chengchuang Song, Xingtang Fang, Yanhong Wang, Chunlei Zhang   +5 more
doaj   +1 more source