Results 11 to 20 of about 174,708,283 (296)

The Role of the Mammalian Target of Rapamycin in Microglial Phenotypic Polarization [PDF]

Cells
Microglia are adaptive immune cells that maintain central nervous system homeostasis and respond dynamically to injury, infection, and other neurological insults.
Kaitlyn J. Partridge, Allison D. Ebert
doaj   +2 more sources

Differential expression of mTOR signalling components in drug resistance in ovarian cancer [PDF]

, 2010
This article has been made available through the Brunel Open Access Publishing Fund and is available from the specified link - Copyright @ 2010 The International Institute of Anticancer Research.Background/Aim: A limitation to successful cancer ...
Karteris, E, Foster, H, Goumenou, A, Pados, G, Harvey, AJ, Coley, HM   +5 more
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Regulation of the mammalian target of rapamycin complex 2 (mTORC2) [PDF]

, 2006
The growth controlling mammalian Target of Rapamycin (mTOR) is a conserved Ser/Thr kinase found in two structurally and functionally distinct complexes, mTORC1 and mTORC2.
Molle, Klaus-Dieter
core   +1 more source

The Potential and Limitations of Precision Oncology: Lessons Learned from Whole-Exome Sequencing in an Exceptional Response to Everolimus in Advanced Renal Cell Carcinoma

Case Reports in Oncology, 2021
Through elucidating the genetic mechanisms of drug sensitivity, precision medicine aims to improve patient selection and response to therapy. Exceptional responders are patients that exhibit exquisite and durable responses to targeted therapy, providing ...
Amanda Pilling, Christopher Wee, Eliezer Bar-Meir, Gregory Dyson, Ok Hwang, Nilesh Gupta, Dhananjay Chitale, Clara Hwang   +7 more
doaj   +1 more source

Blocking Mammalian Target of Rapamycin (mTOR) Alleviates Neuropathic Pain Induced by Chemotherapeutic Bortezomib

Cellular Physiology and Biochemistry, 2018
Background/Aims: Bortezomib (BTZ) is largely used as a chemotherapeutic agent for the treatment of cancer. However, one of the significant limiting complications of BTZ is painful peripheral neuropathy during BTZ therapy. Drugs preventing and/or treating
Zongsheng Duan, Jing Li, Xiaochuan Pang, Hushan Wang, Zhenbo Su   +4 more
doaj   +1 more source

SIRT1 negatively regulates the mammalian target of rapamycin. [PDF]

PLoS ONE, 2010
The IGF/mTOR pathway, which is modulated by nutrients, growth factors, energy status and cellular stress regulates aging in various organisms. SIRT1 is a NAD+ dependent deacetylase that is known to regulate caloric restriction mediated longevity in model
Hiyaa Singhee Ghosh, Michael McBurney, Paul D Robbins   +2 more
doaj   +1 more source

Aliskiren attenuates cardiac dysfunction by modulation of the mTOR and apoptosis pathways [PDF]

Brazilian Journal of Medical and Biological Research, 2020
Aliskiren (ALS) is well known for its antihypertensive properties. However, the potential underlying the molecular mechanism and the anti-hypertrophic effect of ALS have not yet been fully elucidated.
Zhengbo Zhao, Han Liu, Dongmei Guo
doaj   +1 more source

Impairing the production of ribosomal RNA activates mammalian target of rapamycin complex 1 signalling and downstream translation factors [PDF]

, 2014
Ribosome biogenesis is a key process for maintaining protein synthetic capacity in dividing or growing cells, and requires coordinated production of ribosomal proteins and ribosomal RNA (rRNA), including the processing of the latter.
Proud, C., Taylor, Peter M., Liu, R., Iadevaia, Valentina, Averous, Julien, Liu, R, Proud, Christopher G., Proud, CG, Taylor, P., Zhang, Z., Taylor, PM, Zhang, Z, Liu, Rui, Iadevaia, V, Zhang, Ze, Averous, J., Averous, J, Iadevaia, V.   +17 more
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Mammalian Target of Rapamycin Inhibition [PDF]

Clinical Cancer Research, 2004
Abstract The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that has been increasingly recognized as key to the regulation of cell growth and proliferation. mTOR either directly or indirectly regulates translation initiation, actin organization, tRNA synthesis, ribosome biogenesis, and many other key cell maintenance ...
openaire   +2 more sources

Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy [PDF]

, 2009
Mammalian target of rapamycin (mTOR) is a key regulator of cell growth that associates with raptor and rictor to form the mTOR complex 1 (mTORC1) and mTORC2, respectively.
Richard-Bulteau, Hélène, Arnaud Ferry, Pende, Mario, Rüegg, Markus,, Hantaï, Daniel, Mario Pende, Le-Marchand-Brustel, Yannick, Kozma, Sara, Corneloup, Claudine, Laetitia Mazelin, Ferrier, Bernard, Hervé Sanchez, Koulmann, Nathalie, Claudine Corneloup, Bigard, Xavier, Daniel Hantaï, Rüegg, Markus, A., Hélène Richard-Bulteau, Mueller, Matthias, Bauché, Stéphanie, Moncollin, Vincent, Roceri, Mila, Jean-François Tanti, Conjard-Duplany, Agnès, Vignaud, Alban, Alban Vignaud, Stéphanie Bauché, Xavier Bigard, Freyssenet, Damien, Agnès Conjard-Duplany, Tanti, Jean-François, Laurent Schaeffer, Thomas, George, Mazelin, Laetitia, Defour, Aurélia, Aurélia Defour, Romanino, Klaas, Damien Freyssenet, Yannick Le-Marchand-Brustel, Bernard Ferrier, Nathalie Koulmann, George Thomas, Sanchez, Hervé, Baas, Dominique, Klaas Romanino, Sara C. Kozma, Mila Roceri, Kozma, Sara C., Rüegg, Markus A., Yann-Gaël Gangloff, Schaeffer, Laurent, Matthias Mueller, Vincent Moncollin, Markus A. Rüegg, Ferry, Arnaud, Gangloff, Yann-Gaël, Dominique Baas, Risson, Valérie, Valérie Risson, Ferrier. Bernard, Kozma, Sara C   +60 more
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