Results 211 to 220 of about 226,271 (312)

Lysosome Evanescence Mediates Autophagic Flux Impairment in Glucose Imbalanced Environments

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Schwann cells (SCs) support axonal function and promote nerve regeneration. This study investigated how various glucose concentrations influence SC viability, oxidative stress, and autophagy, which contribute to diabetic neuropathy. RSC96 SCs were cultured under five glucose conditions (0, 2.5, 5.5, 50, or 100 mM) for 24, 48, and 72 h.
Yuan‐Chen Cheng, Ling‐Li Chang, Hung‐Chen Wang, Wei‐Chun Hung, Chia‐Hua Hsieh, Yi‐Hsuan Wang, Kuang‐I Cheng   +6 more
wiley   +1 more source

Targeting spinal mechanistic target of rapamycin complex 2 alleviates inflammatory and neuropathic pain. [PDF]

Brain
Wong C, Rodriguez-Hernandez LD, Lister KC, Gu N, Cai W, Hooshmandi M, Fan J, Brown N, Nguyen V, Ribeiro-da-Silva A, Bonin RP, Khoutorsky A.   +11 more
europepmc   +1 more source

Exome Sequencing Identifies Variants in MLH1 and ERBB2 as Potential Cancer‐Predisposing Factors in Familial Early‐Onset Colorectal Cancer

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Colorectal cancer (CRC) has raised considerable health concerns worldwide, with increasing incidence rates, specifically among younger populations. Despite remarkable progress in diagnosing and treating various diseases, the genetic basis of CRC remains only partially understood.
Behnaz Bagheri, Neda Mohsen‐Pour, Najmeh Salehi, Pardis Ketabi Moghadam, Adel Zeinalpour, Amir Sadeghi, Samira Kalayinia, Nayeralsadat Fatemi   +7 more
wiley   +1 more source

Targeting mechanistic target of rapamycin complex 2 attenuates immunopathology in systemic lupus erythematosus.

Rheumatology (Oxford)
Ai M, Zhou X, Carrer M, Jafar-Nejad P, Li Y, Gades N, Alexander M, Bautista-Vargas M, Duarte-García A, Zeng H.   +9 more
europepmc   +1 more source

Adenosine Monophosphate-Activated Protein Kinase Activation and Mammalian Target of Rapamycin Complex 1 Inhibition: A Mechanistic Rationale for Anti-Aging Therapy in Type 2 Diabetes. [PDF]

J Clin Med Res
Yanai H, Adachi H, Hakoshima M, Katsuyama H.   +3 more
europepmc   +1 more source

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

Mammalian target of rapamycin inhibitors as the treatment for steroid-refractory acute graft-vs.-host disease after allogeneic hematopoietic stem cell transplantation: A systematic review and individual patient data meta-analysis. [PDF]

Exp Ther Med
Guo Y, Li Z, Zhang Y, Pan Z, Sun J, Zhang Y, Chang S, Guo Z.   +7 more
europepmc   +1 more source

Nociceptor deletion of Tsc2 enhances axon regeneration by inducing a conditioning injury response in dorsal root ganglia [PDF]

, 2019
Carlin, Dan, Cavalli, Valeria, Ewan, Eric E, Halevi, Alexandra E, Moore, Amy M   +4 more
core   +1 more source

Triacylglycerol‐Based Insulin Resistance Indices and Post‐Transplantation Diabetes Mellitus After Liver Transplantation

Lipids, EarlyView.
ABSTRACT Background: Post‐transplant diabetes mellitus (PTDM) is a common complication following liver transplant (LT) and is associated with adverse outcomes. The triacylglycerol‐glucose product (TyG) and the triacylglycerol‐to‐high‐density lipoprotein (HDL) cholesterol ratio (TAG/HDL‐c) are indices that can serve as triacylglycerol‐based proxies for ...
Mateo Chvatal‐Medina, Yakun Li, Adrian Post, Margery A. Connelly, Han Moshage, Stephan J. L. Bakker, Vincent E. de Meijer, Hans Blokzijl, Robin P. F. Dullaart, on behalf of TransplantLines investigators   +9 more
wiley   +1 more source

Bimetallic Copper-Manganese Zeolitic Imidazolate Framework Nanozyme Scavenges Reactive Oxygen Species to Alleviate Osteoarthritis via Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Axis and Autophagic Flux Restoration. [PDF]

Biomater Res
Zheng X, Zhao S, Li S, Wang Y, Shi J, Qiu Y, Wu X, Zhao Y, Jia T, Dai T.   +9 more
europepmc   +1 more source