Results 231 to 240 of about 226,271 (312)

Inhibition of nuclear receptor coactivator 5 overcomes acquired lenvatinib resistance driven by protein kinase B-mammalian target of rapamycin signaling in hepatocellular carcinoma. [PDF]

Anticancer Drugs
Zhou H, Zhang Q, Yang L, Pan Z, Zheng H, Zhang Z, Li D, Li G, Liu X, Bao X, Liu C, Zhang W.   +11 more
europepmc   +1 more source

Alterations in Metabolites Associated With Umbilical Cord Blood in Monozygotic Twins Discordant for Congenital Heart Disease

Pediatric Discovery, EarlyView.
This study found that the metabolomic signature of umbilical venous cord blood in congenital heart disease (CHD) differs from that of healthy monozygotic (MZ) co‐twins. Dysregulation of metabolic pathways like glucose, lipid, and amino acid metabolism, along with altered metabolites, helps understand CHD predisposition.
Fang Xiang, Xiao Yuan, Yi Yang, Philip N. Baker, Mark D. Kilby, Chao Tong, Xi Yuan   +6 more
wiley   +1 more source

A Gain-of-Function Mutation in Mechanistic Target of Rapamycin Results in a Tuberous Sclerosis Complex-Like Manifestation of Parenchymal Lung Disease. [PDF]

Chest
Bolig TC, Yeldandi AV, Dematte JE, Esposito AJ.   +3 more
europepmc   +1 more source

Kaposiform hemangioendothelioma: Diagnosis and treatment

Pediatric Investigation, EarlyView.
Vascular endothelial growth factor‐C (VEGF‐C)/vascular endothelial growth factor receptor‐3 (VEGFR‐3) and angiopoietin‐2 (Ang‐2)/tyrosine kinase with immunoglobulin‐like and EGF‐like domain 2 (TIE2) signaling pathways play an important role in lymphangiogenesis.
Yi Tian, Yuanyuan Tian, Li Wei, Zigang Xu, Li Li, Lin Ma   +5 more
wiley   +1 more source

Target of rapamycin signaling regulates starch degradation via α-glucan water dikinase in a unicellular red alga. [PDF]

Plant Physiol
Komiya S, Pancha I, Shima H, Igarashi K, Tanaka K, Imamura S.   +5 more
europepmc   +1 more source

Uric Acid in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Portal Hypertension &Cirrhosis, EarlyView.
MASLD is the most prevalent chronic liver disease worldwide, yet effective pharmacological treatments remain limited. Hyperuricemia is now recognized as a key driver of hepatic steatosis, inflammation, and fibrosis, with elevated serum uric acid levels independently predicting hepatocellular carcinoma and liver‐related mortality.
Rong Wang, Zhenyu Liu, Jun Lin, Weijing Zhang, Xianzhi Liu, Tong Zhang   +5 more
wiley   +1 more source

The Regulatory-associated protein of target of rapamycin 1B (RAPTOR 1B) interconnects with the photoperiod pathway to promote flowering in Arabidopsis. [PDF]

Proc Natl Acad Sci U S A
Urrea-Castellanos R, Calderan-Rodrigues MJ, Artins A, Musialak-Lange M, Macharanda-Ganesh A, Fernie AR, Wahl V, Caldana C.   +7 more
europepmc   +1 more source

From flower buds to bolls: how cotton reproductive structures shape boll weevil development, reproduction and survival

Pest Management Science, EarlyView.
Female boll weevils feeding on flower buds promote reproduction regardless of their immature diet, whereas boll feeding increases lipid reserves and lifespan, revealing a nutrition‐driven trade‐off that sustains survival and reproduction in tropical boll weevil populations.
Roberta Ramos Coelho, Guilherme Gomes Rolim, Franklin Magliano da Cunha, Valéria Wanderley‐Teixeira, José Dijair Antonino, Jorge Braz Torres   +5 more
wiley   +1 more source

RETRACTION: Wound Complications Frequency in Heart Transplant Recipients on Mammalian Target of Rapamycin Inhibitors: A Meta-Analysis. [PDF]

Int Wound J
europepmc   +1 more source

Acupuncture improves perimenopausal depression via a mechanism involving activation of the phosphatidylinositol 3-kinase/serine-threonine protein kinase/mechanistic target of rapamycin pathway in a rat model. [PDF]

Neuroreport
Zheng L, Sun Z, Yao S, Jin Y, Liu C.
europepmc   +1 more source