Results 31 to 40 of about 226,271 (312)

TAK1-dependent autophagy: A suppressor of fatty liver disease and hepatic oncogenesis. [PDF]

, 2014
In addition to regulating the activation of nuclear factor (NF)-κB and c-Jun N-terminal kinase (JNK), TGF-β activated kinase 1 (TAK1) also upregulates the activation of AMP-activated protein kinase (AMPK) and autophagy.
Seki, Ekihiro
core   +2 more sources

Rapamycin and Glucose-Target of Rapamycin (TOR) Protein Signaling in Plants [PDF]

Journal of Biological Chemistry, 2012
Target of rapamycin (TOR) kinase is an evolutionarily conserved master regulator that integrates energy, nutrients, growth factors, and stress signals to promote survival and growth in all eukaryotes. The reported land plant resistance to rapamycin and the embryo lethality of the Arabidopsis tor mutants have hindered functional dissection of TOR ...
Yan, Xiong, Jen, Sheen
openaire   +2 more sources

Mammalian/mechanistic target of rapamycin (mTOR) complexes in neurodegeneration

Molecular Neurodegeneration, 2021
Novel targets to arrest neurodegeneration in several dementing conditions involving misfolded protein accumulations may be found in the diverse signaling pathways of the Mammalian/mechanistic target of rapamycin (mTOR).
Henry Querfurth, Han-Kyu Lee
doaj   +1 more source

Prior Treatment with AICAR Causes the Selective Phosphorylation of mTOR Substrates in C2C12 Cells

Current Issues in Molecular Biology, 2023
Metabolic stress in skeletal muscle cells causes sustained metabolic changes, but the mechanisms of the prolonged effects are not fully known. In this study, we tested C2C12 cells with the AMP-activated protein kinase (AMPK) stimulator AICAR and measured
Cass J. Dedert, Kazimir R. Bagdady, Jonathan S. Fisher   +2 more
doaj   +1 more source

GSK3-mediated raptor phosphorylation supports amino acid-dependent Q2 mTORC1-directed signalling [PDF]

, 2015
The mammalian or mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) is a ubiquitously expressed multimeric protein kinase complex that integrates nutrient and growth factor signals for the co-ordinated regulation of cellular metabolism and cell ...
Alan Prescott, Averous, Avruch, Azoulay-Alfaguter, Bain, Bar-Peled, Bar-Peled, Bradford, Carriere, Carriere, Clare Stretton, Coghlan, Cross, Demetriades, Dibble, Doble, Fonseca, Foster, Frey, Ganley, Garcia-Martinez, Gwinn, Gwinn, Hajduch, Hara, Harinder S. Hundal, Hosokawa, Ian G. Ganley, Inoki, Inoki, Inoki, Jewell, Jung, Kelleher, Kim, Kim, Kwak, Lipina, MacAulay, Marchand, Martina, Meijer, Menon, Michael J. Munson, Oshiro, Oshiro, Parr, Peter M. Taylor, Pfaffl, Ramirez-Valle, Rebsamen, Sancak, Shin, Smith, Stretton, Sutherland, Thorsten M. Hoffmann, Wang, Wang, Yoon, Zoncu   +60 more
core   +3 more sources

The TOR Signaling Network in the Model Unicellular Green Alga Chlamydomonas reinhardtii

Biomolecules, 2017
Cell growth is tightly coupled to nutrient availability. The target of rapamycin (TOR) kinase transmits nutritional and environmental cues to the cellular growth machinery. TOR functions in two distinct multiprotein complexes, termed TOR complex 1 (TORC1)
María Esther Pérez-Pérez, Inmaculada Couso, José L. Crespo   +2 more
doaj   +1 more source

SIRT1 negatively regulates the mammalian target of rapamycin. [PDF]

PLoS ONE, 2010
The IGF/mTOR pathway, which is modulated by nutrients, growth factors, energy status and cellular stress regulates aging in various organisms. SIRT1 is a NAD+ dependent deacetylase that is known to regulate caloric restriction mediated longevity in model
Hiyaa Singhee Ghosh, Michael McBurney, Paul D Robbins   +2 more
doaj   +1 more source

The mTOR–Autophagy Axis and the Control of Metabolism

Frontiers in Cell and Developmental Biology, 2021
The mechanistic target of rapamycin (mTOR), master regulator of cellular metabolism, exists in two distinct complexes: mTOR complex 1 and mTOR complex 2 (mTORC1 and 2).
Nerea Deleyto-Seldas, Alejo Efeyan
doaj   +1 more source

Placental DEPTOR as a stress sensor during pregnancy [PDF]

, 2011
The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Non-Commercial Licence (http://creativecommons.org/licenses/by-nc/2.5/) which permits unrestricted non-commercial use, distribution and ...
Gidron, Y, Goumenou, A, Karteris, E, Mparmpakas, D, Zachariades, E   +4 more
core   +2 more sources

Targeting the Mammalian Target of Rapamycin in Lung Cancer [PDF]

The American Journal of the Medical Sciences, 2016
Lung cancer is the leading cause of cancer death worldwide. Despite advances in its prevention and management, the prognosis of patients with lung cancer remains poor. Therefore, much attention is being given to factors that contribute to the development of this disease, the mechanisms that drive oncogenesis and tumor progression and the search for ...
Glenn W, Vicary, Jesse, Roman
openaire   +2 more sources