Results 101 to 110 of about 1,394,726 (329)

Emergence of knock-down resistance in the Anopheles gambiae complex in the Upper River Region, The Gambia, and its relationship with malaria infection in children

Malaria Journal, 2018
Background Insecticide resistance threatens malaria control in sub-Saharan Africa. Knockdown resistance to pyrethroids and organochlorines in Anopheles gambiae sensu lato (s.l.) is commonly caused by mutations in the gene encoding a voltage-gated sodium ...
Anne L. Wilson, Margaret Pinder, John Bradley, Martin J. Donnelly, Majidah Hamid-Adiamoh, Lamin B. S. Jarju, Musa Jawara, David Jeffries, Ballah Kandeh, Emily J. Rippon, Kolawole Salami, Umberto D’Alessandro, Steven W. Lindsay   +12 more
doaj   +1 more source

Target-site mutations (AChE and kdr), and PSMO activity in codling moth (Cydia pomonella (L.) (Lepidoptera: Tortricidae)) populations from Spain [PDF]

, 2018
Codling moth, Cydia pomonella (L.) is a key pest of global importance that affects apple fruit production and whose populations have developed resistance to insecticides in many apple production areas.
Avilla Hernández, Jesús, Bosch Serra, Dolors, Musleh, Selim, Rodríguez García, Marcela   +3 more
core   +3 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Insight into the herbicide resistance patterns in Lolium rigidum populations in Tunisian and Moroccan wheat regions

Frontiers in Plant Science
Rigid ryegrass (Lolium rigidum Gaud.) is one of the most troublesome weeds in Moroccan and Tunisian cereal crop fields. In total, 19 rigid ryegrass field populations were randomly selected in northern wheat crop areas of Morocco and Tunisia to examine ...
Zakia El-Mastouri, Pavlína Košnarová, Kateřina Hamouzová, Ezzedine Alimi, Josef Soukup   +4 more
doaj   +1 more source

Confirmation and Characterization of the First Case of Acetolactate Synthase (ALS)-Inhibitor—Resistant Wild Buckwheat (Polygonum convolvulus L.) in the United States

Agronomy, 2020
Wild buckwheat (Polygonum convolvulus L.) is a problem weed and ALS-inhibitors (e.g., chlorsulfuron) are commonly used for its management. Recently, a population of wild buckwheat (KSW-R) uncontrolled with ALS-inhibitors was found in a wheat field in ...
Balaji Aravindhan Pandian, Abigail Friesen, Martin Laforest, Dallas E. Peterson, P. V. Vara Prasad, Mithila Jugulam   +5 more
doaj   +1 more source

Insecticide Resistance Profiling of Anopheles coluzzii and Anopheles gambiae Populations in the Southern Senegal: Role of Target Sites and Metabolic Resistance Mechanisms [PDF]

, 2020
Oumou Kalsom Gueye, Magellan Tchouakui, Abdoulaye Kane Dia, Mouhamed Bachir Faye, Amblat Ali Ahmed, Murielle J. Wondji, Daniel Nguete Nguiffo, Leon M. J. Mugenzi, Frédéric Tripet, Lassana Konaté, Abdoulaye Diabaté, Ibrahima Dia, Oumar Gaye, Ousmane Faye, El Hadji Amadou Niang, Charles S. Wondji   +15 more
openalex   +1 more source

Targeting Mannitol Metabolism as an Alternative Antimicrobial Strategy Based on the Structure-Function Study of Mannitol-1-Phosphate Dehydrogenase in Staphylococcus aureus [PDF]

, 2019
Mannitol-1-phosphate dehydrogenase (M1PDH) is a key enzyme in Staphylococcus aureus mannitol metabolism, but its roles in pathophysiological settings have not been established.
Bae, Taeok, Chaurasia, Akhilesh Kumar, Choi, Jongkeun, Kim, Kyeong Kyu, Kim, Truc, Lee, Seung Seo, Mizar, Pushpak, Nguyen, Thanh, Ta, Hai Minh, Yeo, Won Sik   +9 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Target Site Insensitivity Detection in Deltamethrin Resistant Culex pipiens Complex in Iran

Iranian Journal of Public Health, 2020
Background: Some mosquito species which belong to the Culex. pipiens complex are primary vectors for West Nile virus, Sindbis, Dirofilaria immitis, and many arboviruses. Knockdown resistance (kdr) mutations in the voltage-gated sodium channel (VGSC) gene of Cx.
Reza ZEIDABADINEZHAD, Hassan VATANDOOST, Mohammad Reza ABAI, Navid DINPARAST DJADID, Abbasali RAZ, Mohammad Mahdi SEDAGHAT, Mohamad Ali OSHAGHI, Ahmad RAEISI, Neda ADIBI   +8 more
openaire   +3 more sources