Results 171 to 180 of about 2,565,028 (307)

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Efficacy and safety of radiofrequency thermocoagulation target therapy for lumbar disc herniation: a systematic review. [PDF]

Front Surg
Cui T, Chen W, Lui C, An J, Zheng W.
europepmc   +1 more source

Novel antioxidant protein target therapy to counter the prevalence and severity of SARS-CoV-2. [PDF]

Front Immunol, 2023
Kaur P, Dey A, Rawat K, Dey S.
europepmc   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Immune-Related Adverse Events in Patients with Melanoma Treated with B-RAF/MEK Target Therapy: Occurrence and Circulating Immune Cell Analysis. [PDF]

Cancers (Basel)
Capone A, Carbone ML, Mastroeni S, Di Pietro FR, Verkhovskaia S, Morese R, Melo N, D'Atri S, De Galitiis F, Falcone R, Fortes C, Volpe E, Failla CM.   +12 more
europepmc   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Efficacy and safety of scheduled rituximab in children with refractory nephrotic syndrome after multi-target therapy failure. [PDF]

Pediatr Nephrol
Yang J, He Y, Pu J, Zhang Y, Zhou J, Qiu L.   +5 more
europepmc   +1 more source

Potential repurposing of DPP4 inhibitors for target therapy resistance in renal cell carcinoma. [PDF]

Oncotarget, 2023
Horie K, Inoue S.
europepmc   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

NUP205 Stabilized YAP1 Protein to Stimulate Growth of Hepatocellular Carcinoma Cells in vitro and in vivo

Journal of Hepatocellular Carcinoma
Huangying Deng,1 Siqi Yu,2 Jing Zhang,2 Yuhang Hou,2 Mei Yang,2 Shengtao Yuan,2 Qiang Tu,3 Meijian Wang1 1Department of Medical Oncology, Jiangxi Cancer Hospital, The Second Affiliated Hospital of Nanchang Medical College, Jiangxi Clinical Research ...
Deng H, Yu S, Zhang J, Hou Y, Yang M, Yuan S, Tu Q, Wang M   +7 more
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