Umbilical cord blood: A promising source for allogeneic CAR-T cells
Frontiers in Oncology, 2022 Chimeric antigen receptor T (CAR-T) cell therapy is an effective treatment for relapsed and refractory acute lymphoblastic leukemia (R/R ALL). However, autologous CAR-T cells derived from patients with B-ALL often show poor amplification ability ...
Dian-Dian Liu +21 more
doaj +1 more source
Rationale and design of the GUIDE-IT study: Guiding Evidence Based Therapy Using Biomarker Intensified Treatment in Heart Failure. [PDF]
, 2014 OBJECTIVES: The GUIDE-IT (Guiding Evidence Based Therapy Using Biomarker Intensified Treatment in Heart Failure) study is designed to determine the safety, efficacy, and cost-effectiveness of a strategy of adjusting therapy with the goal of achieving and
Adams, Kirkwood F. +15 more
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Tetrahydroimidazo[4,5-c]pyridine-Based Inhibitors of Porphyromonas gingivalis Glutaminyl Cyclase
Pharmaceuticals, 2021 Periodontitis is a severe yet underestimated oral disease. Since it is linked to several systemic diseases, such as diabetes, artheriosclerosis, and even Alzheimer’s disease, growing interest in treating periodontitis has emerged recently.
Daniel Ramsbeck +5 more
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Journal of Pharmacological Sciences, 2019 Acute myeloid leukemia (AML) is the most common subtype of hematological malignancy in humans, and its incidence increases with age. The treatment of AML still faces challenges.
Wenjing Ma +10 more
doaj +1 more source
Next-Generation Sequencing: Targeting Targeted Therapies [PDF]
Clinical Cancer Research, 2015 Abstract Next-generation sequencing (NGS) has given new perspective in oncology. With the ongoing development of targeted therapies, NGS is evolving molecular diagnostics by providing comprehensive interrogation of clinically actionable genomic aberrations in tumors.
Justine N, McCutcheon +1 more
openaire +2 more sources
Amyloid-Beta Peptides Trigger Aggregation of Alpha-Synuclein In Vitro
Molecules, 2020 Alzheimer’s disease (AD) and Parkinson’s disease (PD), including dementia with Lewy bodies (DLB), account for the majority of dementia cases worldwide.
Janett Köppen +14 more
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A chemogenomic screening identifies CK2 as a target for pro-senescence therapy in PTEN-deficient tumours [PDF]
, 2015 Enhancement of cellular senescence in tumours triggers a stable cell growth arrest and activation of an antitumour immune response that can be exploited for cancer therapy.
Alajati, Abdullah +25 more
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Targeting BCL-2 regulated apoptosis in cancer [PDF]
, 2018 The ability of a cell to undergo mitochondrial apoptosis is governed by pro- and anti-apoptotic members of the BCL-2 protein family. The equilibrium of pro- versus anti-apoptotic BCL-2 proteins ensures appropriate regulation of programmed cell death ...
Campbell, Kirsteen J. +1 more
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Co-targeting of DNA, RNA, and protein molecules provides optimal outcomes for treating osteosarcoma and pulmonary metastasis in spontaneous and experimental metastasis mouse models. [PDF]
, 2017 Metastasis is a major cause of mortality for cancer patients and remains as the greatest challenge in cancer therapy. Driven by multiple factors, metastasis may not be controlled by the inhibition of single target.
DeVere White, Ralph W +11 more
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Accuracy of a magnetic resonance imaging‐based 3D printed stereotactic brain biopsy device in dogs [PDF]
, 2020 Background: Brain biopsy of intracranial lesions is often necessary to determine specific therapy. The cost of the currently used stereotactic rigid frame and optical tracking systems for brain biopsy in dogs is often prohibitive or accuracy is not ...
Böttcher, Peter +8 more
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