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Cancer, 1986
Cancer chemotherapy drugs are neither specific, i.e., they do not act exclusively on the metabolic pathways of cancer cells, nor are they targeted solely toward cancer cells. However, recent research has begun to address, in part, the latter issue. Improved delivery of chemotherapeutic agents to tumor tissue in man appears to be an achievable goal in ...
A I, Freeman, E, Mayhew
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Cancer chemotherapy drugs are neither specific, i.e., they do not act exclusively on the metabolic pathways of cancer cells, nor are they targeted solely toward cancer cells. However, recent research has begun to address, in part, the latter issue. Improved delivery of chemotherapeutic agents to tumor tissue in man appears to be an achievable goal in ...
A I, Freeman, E, Mayhew
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Advances in drug delivery and targeting
Current Opinion in Oncology, 1991This review covers a variety of techniques aimed at improving the specificity of delivery of both biologic and cytotoxic agents to tumor tissue while sparing normal tissue. The major areas reported on include further attempts to increase the ability of monoclonal antibodies, both conjugated and unconjugated, to target tumor tissue. It also examines the
D, Goldstein, C, Lewis
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Targeted drug delivery to macrophages
Expert Opinion on Drug Delivery, 2013Targeted drug delivery to the macrophages appears to be an attractive proposition to improve therapeutic efficacy of enclosed drug. Thus, macrophages can be exploited as Trojan horses for targeted drug delivery. Nanocarriers can migrate across the different membrane barriers and release their drug cargo at sites of infection.This review discusses the ...
Narendra K, Jain +2 more
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Chemical Reviews, 2017
Safety and efficacy constitute the major criteria governing regulatory approval of any new drug. The best method to maximize safety and efficacy is to deliver a proven therapeutic agent with a targeting ligand that exhibits little affinity for healthy cells but high affinity for pathologic cells.
Madduri Srinivasarao, Philip S. Low
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Safety and efficacy constitute the major criteria governing regulatory approval of any new drug. The best method to maximize safety and efficacy is to deliver a proven therapeutic agent with a targeting ligand that exhibits little affinity for healthy cells but high affinity for pathologic cells.
Madduri Srinivasarao, Philip S. Low
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Targeted drug delivery to melanoma
Advanced Drug Delivery Reviews, 2018Melanoma derived from melanocytes is the most aggressive genre of skin cancer. Although the considerable advancement in the study of human cancer biology and drug discovery, most advanced melanoma patients are inevitably unable to be cured. With the emergence of nanotechnology, the use of nano-carriers is widely expected to alter the landscape of ...
Das, Manisit +3 more
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Alginate Nanoparticles for Drug Delivery and Targeting
Current Pharmaceutical Design, 2019Nanotechnology refers to the control, manipulation, study and manufacture of structures and devices at the nanometer size range. The small size, customized surface, improved solubility and multi-functionality of nanoparticles will continue to create new biomedical applications, as nanoparticles allow to dominate stability, solubility and ...
Severino, Patricia +5 more
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Drug Targets, Drug Effectors, and Drug Targeting and Delivery
2012The chemotherapy of leishmaniases has undergone significant improvements during the last decade with the use of liposomal amphotericin B formulation (AmBisome®) and miltefosine as the first orally active drug. However, whatever the proposed treatment, limitations such as adverse effects and the emergence of drug resistance justify the search for new ...
Philippe M. Loiseau, Gillian Barratt
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Expert Opinion on Therapeutic Patents, 1999
Creating effective targeted drug delivery strategies is an integral component of the overall process of drug development. The four key requirements of an effective drug delivery system are retain, evade, target and release. Increasing the therapeutic index (TI) of a delivered compound by selectively delivering it to target areas is a goal that has many
Jeffrey K Mills, David Needham
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Creating effective targeted drug delivery strategies is an integral component of the overall process of drug development. The four key requirements of an effective drug delivery system are retain, evade, target and release. Increasing the therapeutic index (TI) of a delivered compound by selectively delivering it to target areas is a goal that has many
Jeffrey K Mills, David Needham
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Physics in Technology, 1985
Conventional forms of drugs normally medicate the whole body, reaching healthy areas as well as diseased. However techniques are now available which are better at restricting drug action to the sites where it is needed.
A T Florence, G W Halbert
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Conventional forms of drugs normally medicate the whole body, reaching healthy areas as well as diseased. However techniques are now available which are better at restricting drug action to the sites where it is needed.
A T Florence, G W Halbert
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