Results 171 to 180 of about 90,676 (185)
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Targeting Metabolomics in Breast Cancer
Current Breast Cancer Reports, 2012Metabolomics is a science that provides a dynamic portrait of the metabolic status of a biological system. Down from genomics, transcriptomics, and proteomics, metabolomics assesses end product metabolites and small intermediate molecules. In oncology, identification and quantification of metabolites and correlation with critical metabolic pathways in ...
Catherine Oakman +5 more
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“Targeted Metabolomics” in der Biomarkerforschung
Angewandte Chemie, 2010AbstractDer Begriff “Metabolomics” bezeichnet ein wissenschaftliches Betätigungsfeld, das im ureigenen Sinn interdisziplinär ist und in dem analytische Chemie, Plattformtechnologie, Massenspektrometrie und NMR‐Spektroskopie sowie Datenanalyse kombiniert zum Einsatz kommen.
William J. Griffiths +5 more
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Comprehensive Targeted Metabolomic Assay for Urine Analysis
Analytical Chemistry, 2020Among all the human biological fluids used for disease biomarker discovery or clinical chemistry, urine stands out. It can be collected easily and noninvasively, it is readily available in large volumes, it is typically free from protein contamination, and it is chemically complex-reflecting a wide range of physiological states and functions.
Jiamin Zheng +4 more
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Targeted Metabolomics on Rare Primary Cells
Journal of Visualized ExperimentsCellular function critically depends on metabolism, and the function of the underlying metabolic networks can be studied by measuring small molecule intermediates. However, obtaining accurate and reliable measurements of cellular metabolism, particularly in rare cell types like hematopoietic stem cells, has traditionally required pooling cells from ...
Glaser, K. +10 more
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Challenges in Mass Spectrometry Based Targeted Metabolomics
Current Molecular Medicine, 2010The gap of the post-genomic era is increasingly being filled by the metabolomics approach, comprising a technology for analyzing small molecule endogenous metabolites (
Koal, Therese, Deigner, Hans-Peter
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Targeted and quantitative metabolomics in bacteria
2012Abstract Targeted metabolomics aims at reliable and sensitive quantification of a subset of metabolites in a cell. Here, we describe our current methods to obtain quantitative intracellular concentrations of a specified set of metabolites in bacteria.
Hannes Link +2 more
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Journal of Proteome Research, 2017
High plant lignan intake is associated with a number of health benefits, possibly induced by the lignan metabolite enterolactone (ENL). The gut microbiota plays a crucial role in converting dietary lignans into ENL, and epidemiological studies have shown that use of antibiotics is associated with lower levels of ENL.
Anne K. Bolvig +7 more
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High plant lignan intake is associated with a number of health benefits, possibly induced by the lignan metabolite enterolactone (ENL). The gut microbiota plays a crucial role in converting dietary lignans into ENL, and epidemiological studies have shown that use of antibiotics is associated with lower levels of ENL.
Anne K. Bolvig +7 more
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How Unbiased is Non-Targeted Metabolomics and is Targeted Pathway Screening the Solution?
Current Pharmaceutical Biotechnology, 2011Metabolomics is only truly unbiased if the whole metabolome is captured. Current metabolomics technologies capture only a part of the metabolome and therefore produce inherently biased results. Important factors that introduce such bias into a metabolomic analysis may include but are not limited to, timing of sample collection, the sample collection ...
Uwe, Christians +3 more
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Functional Analysis of Protein Targets by Metabolomic Approaches
2011Proteomics methods, such as activity-based protein profiling, can be used to connect proteins to biology and disease. Some proteins found through unbiased methods are not well characterized, which makes it difficult to ascertain the role of these proteins.
Yun-Gon, Kim, Alan, Saghatelian
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