Results 211 to 220 of about 7,670,364 (343)

Targeting the PHB2–ACSL3 Lipid‐Remodeling Axis Overcomes Cisplatin Resistance by Restoring Ferroptosis in Gastric Cancer

Advanced Science, EarlyView.
ABSTRACT Platinum‐based chemotherapy resistance remains a major obstacle in gastric cancer (GC) treatment. Through integrated transcriptomic profiling of cisplatin‐resistant xenografts and pharmacogenomic interrogation of the NCI‐60 dataset, we identified Prohibitin‐2 (PHB2) as a previously unrecognized determinant of chemoresistance.
Liang Xu, Wanying Xiang, Xinyue Wang, Yue Pan, Jing Gao, Jiezhen Yang, Yufei Wang, Zhipu Zhu, Man Tong, Lei Jin, Yan Ye   +10 more
wiley   +1 more source

Characterise the Response of Amorphophallus konjac to Different Shading Gradients Through Non-Target Metabolomics

Hongkun Li, Shouling Li, Siwei Pu, Xun Shi, Chunlan Meng, 高誓男, Shanshan Yin, Minghua Luo   +7 more
openalex   +1 more source

Gut-selective integrin-targeted therapy improves metabolic pathways in the early immune activation mouse model of autism spectrum disorder as revealed by untargeted metabolomics [PDF]

Giuseppina Fanelli, Veronica Lelli, Rosa Luisa Potenza, Laura Ricceri, Roberta De Simone, Monica Boirivant, Alessia Butera, Anna Maria Timperio   +7 more
openalex   +1 more source

Repurposing FDA‐Approved Drugs to Inhibit Fungal PPTases for Broad‐Spectrum Synergy

Advanced Science, EarlyView.
Fungal secondary metabolites serve as crucial virulence effectors; however, the potential of their biosynthetic pathways as antifungal targets remains inadequately comprehended. Repurposed FDA‐approved drugs inhibit fungal PPTase (essential for secondary metabolism) in vivo.
Zili Song, Can Zhao, Qiaoling Wang, Hongjiao Zhang, Xiao Liu, Linqi Wang, Michael Bromley, Wen‐Bing Yin   +7 more
wiley   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

Optimization of a targeted metabolomics kit for dried blood spots analysis and longitudinal comparison with serum. [PDF]

Metabolomics
Bossi E, Prehn C, Crotti L, Malfatto G, Paglia G, Witting M.   +5 more
europepmc   +1 more source

Time-Resolved Transcriptomic and Widely Targeted Metabolomic Profiling of Tomato Seedlings During Short-Term Chilling

Dan Zhou, Zijun Yan, Tao Yan, Xiumei Fan, Zijuan Xu, Tianhong Wang, Xiaocui Chen, 苟晓松, Sheng Sun, Zhifeng Chen   +9 more
openalex   +1 more source

ACSL4‐Dependent Lysosomal Lipid Peroxidation Links WTAP‐Mediated m6A Modification to Intervertebral Disc Degeneration

Advanced Science, EarlyView.
IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia, Xu Gao, Laimin Zhu, Haixia Song, Jing Wu, Shang Chen, Sheng Gao, Lu Zhang, Chunyang Meng   +8 more
wiley   +1 more source

Role of the gut microbiota-bile acid axis in liver fibrosis based on microbiomics and targeted metabolomics. [PDF]

BMC Microbiol
Zhang YL, Gou HZ, Li ZJ, Xi JH, Wang XJ, Shang J, Zhu D, Ren LF, Shu XJ, Zhang L.   +9 more
europepmc   +1 more source

Supplementary datasets for polyphenol widely targeted metabolomics analysis in walnut endopleura

Liu Jing
openalex   +1 more source