Results 161 to 170 of about 38,995 (207)

The PART randomised trial protocol: Partial Ablation versus Radical Treatment for prostate cancer

BJU International, EarlyView.
Objectives Primary objective: to determine whether prostate gland partial ablation (PA) has non‐inferior oncological treatment success vs radical treatment (RT) of localised intermediate‐risk prostate cancer (irPCa). Secondary objectives: to compare (i) participant‐reported urinary and sexual dysfunction side effects, (ii) short/medium term serious ...
Richard J. Bryant, Tom Leslie, Marc Laniado, Abhishek Sharma, Alistair Grey, John Withington, Christopher Blick, Edward Streeter, Sanjeev Kotwal, Oliver Hulson, William Cross, Daniel W. Good, Altan Omer, Taimur T. Shah, Nishant Bedi, Luke Stroman, Caroline Moore, Prasanna Sooriakumaran, Hashim U. Ahmed, Simon F. Brewster, Vicki S. Barber, Aimi Hewitt, Clare Calvert, Jessica Scaife, Derek Shepherd, Filipa Landeiro, Jane Wolstenholme, Philip Camilleri, Clare Verrill, Shelagh Lovell, Martin Pirkl, Fergus Gleeson, Roxanne Williams, Jo Cook, Catherine R. Holt, Martyn Hill, Jonathan Cook, James Radford, Ioana R. Marian, Ruth Macpherson, Daisy Elliott, Jenny L. Donovan, Freddie C. Hamdy   +42 more
wiley   +1 more source

3.0-T MR-guided transgluteal in-bore-targeted prostate biopsy under local anesthesia in patients without rectal access: a single-institute experience and review of literature. [PDF]

Abdom Radiol (NY)
Bera K, Ramaiya N, Paspulati RM, Nakamoto D, Tirumani SH.   +4 more
europepmc   +1 more source

The role of PSA density in the follow up of men with a negative MRI in the Göteborg‐2 trial

BJU International, EarlyView.
Objectives To assess whether prostate‐specific antigen density (PSAD) stratifies long‐term risk of clinically significant prostate cancer (csPCa) after a negative magnetic resonance imaging (MRI; Prostate Imaging‐Reporting and Data System score ≤2) and to evaluate the potential of PSAD to guide follow‐up in a screening setting.
Fredrik Möller, Marianne Månsson, Mikael Hellström, Fredrik Langkilde, Vasiliki Spyratou, Johan Stranne, Jonas Wallström, Jonas Hugosson, Rebecka Arnsrud Godtman   +8 more
wiley   +1 more source

Prostate cancer detection and complications of MRI-targeted prostate biopsy using cognitive registration, software-assisted image fusion or in-bore guidance: a systematic review and meta-analysis of comparative studies. [PDF]

Prostate Cancer Prostatic Dis
Falagario UG, Pellegrino F, Fanelli A, Guzzi F, Bartoletti R, Cash H, Pavlovich C, Emberton M, Carrieri G, Giannarini G.   +9 more
europepmc   +1 more source

Patient-reported pain, discomfort, and anxiety during magnetic resonance imaging-targeted prostate biopsy. [PDF]

Can Urol Assoc J, 2020
Chesnut GT, Zareba P, Sjoberg DD, Mamoor M, Carlsson S, Lee T, Fainberg J, Vertosick E, Manasia M, Schoen M, Ehdaie B.   +10 more
europepmc   +1 more source

Extracellular vesicles in pharmacology: Innovations in drug delivery and therapeutic applications in cancer

British Journal of Pharmacology, EarlyView.
Extracellular vesicles (EVs) are a diverse population of membrane nanoparticles secreted by nearly all cell types, playing a key role in intercellular communication by transferring bioactive macromolecular cargo. In cancer, EVs shape both the local tumour microenvironment and distant premetastatic niches.
Evangelia Pantazaka, Georgios Sivvas, Evangelia Papadimitriou, Constantinos M. Mikelis   +3 more
wiley   +1 more source

Evidence That the Protein Phosphatase Activity of PTEN Contributes to Embryonic Development and Tumor Suppression

Cancer Science, EarlyView.
Mice expressing only mutant PTEN Y138L, a protein which shows normal suppression of cellular AKT yet lacks protein phosphatase activity, die in utero, and heterozygous mice display a range of tumors. This indicates both the lipid and protein phosphatase activities of PTEN work together for normal tumor suppression and embryonic development.
Priyanka Tibarewal, Laura Spinelli, Nisha Kriplani, Helen Wise, Nadege Poncet, Giulia Marzano, Karen E. Anderson, Katarzyna M. Grzes, Zofia Varyova, Mahreen Adil, C. Peter Downes, Phillip T. Hawkins, Len R. Stephens, Kate G. Storey, Doreen A. Cantrell, Bart Vanhaesebroeck, Nicholas R. Leslie   +16 more
wiley   +1 more source

Liquid Biopsy and Multi‐Cancer Early Detection Tests for Cancer Screening: A Scoping Review

Clinical Genetics, EarlyView.
There is a large body of evidence on liquid biopsy and multi‐cancer detection tests for cancer screening. Most studies addressed test performance outcomes, while fewer addressed clinical outcomes, implementation, and cost‐effectiveness. No studies evaluated cancer mortality.
Tessa Robinson, Marian Saab, Lily Thao Nguyen, Pooja Kochar, Olivia Meggetto, Jill Tinmouth, Meghan J. Walker   +6 more
wiley   +1 more source

Prostate‐specific membrane antigen (PSMA)‐PET‐avid prostate cancers show stronger PSMA immunohistochemistry staining on biopsy cores

BJU International, EarlyView.
Jonathon Carll, Henry Yen‐Cheng Pan, Nathan Lawrentschuk, Andrew Ryan   +3 more
wiley   +1 more source

Bringing Gene Therapy Into Real World Clinical Practice

Haemophilia, EarlyView.
ABSTRACT Introduction Adeno‐associated virus (AAV)‐based gene therapy for haemophilia has shifted therapeutic paradigms by enabling hepatic gene transfer, restoring endogenous clotting factor expression, and reducing reliance on conventional prophylactic treatments. Two products, valoctocogene roxaparvovec (haemophilia A) and etranacogene dezaparvovec (
Wolfgang Miesbach, Pratima Chowdary, Margareth C. Ozelo   +2 more
wiley   +1 more source