Results 181 to 190 of about 38,995 (207)

Economic value and clinical role of minimally invasive, biopsy‐based diagnostics in non‐small cell lung cancer

Cancer Cytopathology, Volume 134, Issue 10, October 2026.
Abstract Background Precision oncology requires diagnostic sampling that delivers molecularly actionable material quickly and safely. In non‐small cell lung cancer (NSCLC), core‐needle biopsy (CNB) remains common. Yet fine‐needle aspiration (FNA) has re‐emerged with rapid on‐site evaluation (ROSE), optimized cell blocks, and next‐generation sequencing.
Jiayuan Guo, Bo Franzén, Rolf Lewensohn, Martin Hysek, Linus Jönsson   +4 more
wiley   +1 more source

Cathepsin L in cancer: Context‐dependent functions, microenvironmental regulation and translational opportunities

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Cathepsin L (CTSL) acts as a context‐dependent facilitator of tumour progression rather than a universal oncogenic driver. CTSL's pro‐tumorigenic functions are critically evaluated alongside its inherent biochemical constraints and family‐wide redundancy. CTSL‐related biology may provide translational opportunities in selected contexts.
Yujun Wu, Qin Huang, Zixuan Ding, Lin Fu, Mu Yang, Bi Peng, Pengbo Hu, Yuanhui Liu   +7 more
wiley   +1 more source

Prevalence of Helicobacter pylori Exposure and Risk Factors Among BRCA1 and BRCA2 Carriers

International Journal of Cancer, Volume 159, Issue 7, Page 1663-1668, 1 October 2026.
BRCA1 and BRCA2 pathogenic germline variant (PGV) carriers may be at increased risk of gastric cancer (GC), especially in the case of prior or active Helicobacter pylori (Hp) infection. The extent to which Hp influences BRCA1 and BRCA2‐associated GC remains uncertain. Here, the authors evaluated plasma samples from a U.S. cohort of BRCA1, BRCA2, PALB2,
Kole H. Buckley, Yuhan Zhu, Kevin Dinh, Ryan Hausler, Rohan Gala, Sophia R. Spiegel, Rosella Delgado, Daniel G. Clay, Gregory M. Kelly, Jamie Brower, Susan M. Domchek, Kara N. Maxwell, Bryson W. Katona   +12 more
wiley   +1 more source

Automatic Conversion of NICE Guidelines to an Executable Computational Model Using Large Language Models

Learning Health Systems, Volume 10, Issue 4, October 2026.
ABSTRACT Introduction The UK National Institute for Health and Care Excellence (NICE) produce guidelines that provide evidence‐based recommendations to support clinical care across England and Wales, but remain available in unstructured natural language form.
Ashvin Gupta, Denys Prociuk, Alessandra Russo, Brendan C. Delaney   +3 more
wiley   +1 more source

The Sleeping Giant: Metabolism and Autophagy in the Generation and Survival of Dormant Polyploid Giant Cancer Cells

MedComm, Volume 7, Issue 10, October 2026.
Polyploid giant cancer cells (PGCCs) arise in response to stress and play a critical role in therapy resistance and tumor dormancy. These cells can evade conventional treatments and later contribute to cancer relapse by generating progeny through nonmitotic, amitotic mechanisms.
Silvia Guil‐Luna, María Teresa Sánchez‐Montero, Alejandra Díaz‐Chacón, Antonio Rodríguez‐Ariza   +3 more
wiley   +1 more source

Extracellular Vesicles: Classification, Biological Functions, Diseases, and Therapeutic Opportunities

MedComm, Volume 7, Issue 10, October 2026.
• EV content maintains cellular homeostasis and is involved in several disease onset and progression. • miRNA export in EVs depends on: RNA‐binding proteins recognizing motif sequences and on epitranscriptomic modifications. • The disclosure of delivery mechanisms is crucial for developing personalized EV‐based therapeutic tools. ABSTRACT Extracellular
Sabrina Garbo, Francesco Marocco, Clemens Zwergel, Marco Tripodi, Cecilia Battistelli   +4 more
wiley   +1 more source

Mucosal‐Associated Invariant T Cells in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao, Feng‐Mi Ou, Dan Liang, Yang Gao, Qing‐Qing Li, Yi‐Qun Kuang   +5 more
wiley   +1 more source

Mesothelin as Biomarker and Therapeutic Target for Immunotherapy in Cancer

MedComm, Volume 7, Issue 10, October 2026.
Mesothelin overexpression activate important pathways like nuclear factor k‐light‐chain‐enhancer of activated B cells (NF‐κB) and interleukin‐6 (IL‐6). This in turn causes numerous cancers, such as pancreatic and ovarian cancers. MSLN‐targeting immunotherapies, like monoclonal antibodies, have shown efficacy.
Manoj Kumar Gupta, Ramakrishna Vadde, Ganji Purnachandra Nagaraju   +2 more
wiley   +1 more source

Targeting the DNA Damage Response in Cancer

MedComm, Volume 7, Issue 10, October 2026.
Targeting the DNA damage response (DDR) reshapes both tumor vulnerability and antitumor immunity. DNA lesions and DDR inhibitors can promote cytosolic nucleic‐acid sensing, antigen presentation, and immune activation, but can also induce adaptive immune escape.
Yihuan Qiao, Boyu Kang, Jian Zhang, Rui Zhang, Jipeng Li   +4 more
wiley   +1 more source

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Genetic testing in prostate cancer management: Considerations informing primary care

Ca-A Cancer Journal for Clinicians, 2022
Mary-Ellen Taplin, Veda Giri, Jacob Berchuck   +2 more
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