Results 41 to 50 of about 38,995 (207)

Is Standard TRUS-Guided Prostate Biopsy the End of the Game?

Urology Research and Practice
Objective: Prostate cancer (PCa) remains a major cause of morbidity and mortality among men worldwide, and histopathologic tissue sampling plays a pivotal role in diagnosis.
Erdal Benli, Nurullah Kadim, Ahmet Yüce, Abdullah Çırakoğlu, Mevlüt Keleş, Ayhan Arslan   +5 more
doaj   +1 more source

OPTIMIZATION OF PRIMARY TRANSRECTAL MULTIFOCAL PROSTATE BIOPSY USING PERFUSION COMPUTED TOMOGRAPHY

Сибирский онкологический журнал, 2018
Introduction. Primary transrectal multifocal prostate biopsy is the standard method for prostate cancer (PCa) verification, with the detection rate of 53 %. The purpose of the study was to improve findings of transrectal ultrasound-guided prostate biopsy
N. V. Sosnovskiy, М. I. Shkolnik, E. V. Rozengauz, D. V. Nesterov   +3 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Prostate Biopsy Results in the PSA Gray Zone: A Five-Year Retrospective Study

Acta Clinica Croatica
Our aim was to analyze and compare the diagnostic efficacy of systematic and targeted + systematic prostate biopsies in patients with prostate-specific antigen (PSA) levels of 4–10 ng/mL.
Tomislav Kuliš, Toni Kelava, Toni Zekulić, Luka Penezić, Jerko Anđelić, Tomislav Sambolić, Željko Kaštelan   +6 more
doaj   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Comparative characteristics of prostate cancer detection by transperineal and transrectal fusion-biopsy

Вестник урологии
Introduction. Prostate biopsy remains the gold standard for the diagnosis of prostate cancer. In contemporary practice, increasing preference is given to fusion biopsy, which is more reliable and informative than conventional ultrasound‑guided systematic
S. V. Popov, I. N. Orlov, A. V. Bashin, T. M. Topuzov, A. V. Tsoi, A. V. Kerechun   +5 more
doaj   +1 more source

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source