Results 191 to 200 of about 464,369 (258)

Targeted Protein Degradation in Cancer: PROTACs, New Targets, and Clinical Mechanisms. [PDF]

Biomolecules
Faryal B, Ul Abideen Z, Irfan M, Ahmed H, Jalilov F, Abduraximova L, Ashraf GA.   +6 more
europepmc   +1 more source

Upcycling Keratin‐Based Textile Waste Into High‐Performance Hybrid Fibers Via Tuning the Interfacial Interactions

Advanced Functional Materials, EarlyView.
Keratin recovered from animal‐hair textile waste is fractionated and blended with cellulose to produce continuously spun hybrid fibers. Selecting the high‐molecular‐weight keratin fraction enables 30 wt.% keratin incorporation while maintaining high strength in dry and wet states.
Mian Zhai, Daniel Van Opdenbosch, Inge Schlapp‐Hackl, Teemu Välisalmi, Markus Linder, Michael Hummel, Wenwen Fang   +6 more
wiley   +1 more source

Native Mass Spectrometry Analysis of Cullin-RING Ubiquitin E3 Ligase Complexes in the Context of Targeted Protein Degradation. [PDF]

Anal Chem
Sternicki LM, Crowe C, Wieske LHE, Ciulli A, Poulsen SA.   +4 more
europepmc   +1 more source

Photo‐Switchable Molecular Module Programming PET Biodegradation in Aquatic Environments

Advanced Functional Materials, EarlyView.
We address the plastic durability paradox by integrating an itaconic acid–derived pyrrolidone module into polymer backbones. Sunlight in water triggers Norrish Type I ring‐opening and hydrophilization, enabling rapid biodegradation into nontoxic minerals.
Mohammad Asif Ali, Jixin Zheng, Satoshi Wakai, Jie Liu, Hidetaka Nomaki, Misato Tsukatani, Noriyuki Isobe, Jingcheng Sang, Yuriko Aoki, Hideo Okamura, Daisuke Sasaki, Chiaki Ogino, Yuzo Yamazaki, Takashi Nishikaze, Kenji Takada, Maiko K. Okajima, Tatsuo Kaneko   +16 more
wiley   +1 more source

Author Correction: Extracellular vesicle-based targeted protein degradation platform for multiple extracellular proteins. [PDF]

EMBO Mol Med
Tong B, Zhang X, Zhu D, Wang Y, Wei J, Ou Z, Liang H, Xu H, Zhang Z, Lei J, Zhou X, Wu D, Song Y, Wang K, Feng X, Tan L, Liao Z, Yang C.   +17 more
europepmc   +1 more source

Covalent Functionalization of 2D Semiconductors: A Roadmap to Advanced Electronic Devices

Advanced Functional Materials, EarlyView.
This Review presents recent advances in the covalent functionalization strategies for two‐dimensional semiconductors and their implementation in modern technologies. Layered materials are modified through diverse molecular chemistries (e.g., thiols, diazonium salts, alkyl halides, and electron‐deficient species) to tailor their surface properties ...
Ramiro Quirós‐Ovies, Bin Han, Paolo Samorì   +2 more
wiley   +1 more source

FDA Approval of the First-Ever PROTAC: Vepdegestrant (ARV-471) Marks a New Era in Targeted Protein Degradation. [PDF]

J Med Chem
Kumar A, Ali S, Shen Q, Zhou J.
europepmc   +1 more source

A cytokine receptor-targeting chimera toolbox for expanding extracellular targeted protein degradation. [PDF]

Proc Natl Acad Sci U S A
Kumru K, Yao Z, Holmes BB, Zhao F, Zhang Y, Ferrara E, Peters-Clarke TM, Leung KK, Wells JA.   +8 more
europepmc   +1 more source

Hydrophobic tagging: A promising paradigm for targeted protein degradation. [PDF]

Cell Insight
Xin L, Wang H, Yang M, Guo Z, Zhu M, Moore TW, Dong C, Zhou HB.   +7 more
europepmc   +1 more source