Advanced Functional Materials, EarlyView.We have developed DEX/GM, an all‐natural, personalizable hybrid vaccine designed by coating dendritic cell‐derived exosomes (DEX) onto tumor cell membranes (GM) for sustained prophylaxis against glioblastoma (GBM). ABSTRACT Glioblastoma (GBM), one of the most aggressive and lethal brain tumors, remains incurable with a poor clinical prognosis.
Shanshan Li +6 more
wiley +1 more source
Correction: Proteolysis targeting chimeras (PROTACs) come of age: entering the third decade of targeted protein degradation. [PDF]
RSC Chem BiolBond MJ, Crews CM.
europepmc +1 more source
In Situ 3D Bioprinting: Impact of Cross‐Linking on the Adhesive Properties of Hydrogels
Advanced Functional Materials, EarlyView.In situ 3D bioprinting enables the direct deposition of cell‐laden, adhesive biomaterials for on‐site tissue regeneration. This review provides a comprehensive overview of how cross‐linking influences the bioadhesive properties of hydrogels used in 3D bioprinting, highlighting cross‐linking triggers, bioadhesion mechanisms, polymer interpenetration ...
Odile Romero Fernandez +4 more
wiley +1 more source
Proof of concept: targeted protein degradation of the stress granules component G3BP1 as an antiviral strategy against norovirus infection. [PDF]
Antimicrob Agents ChemotherEchavarria-Consuegra L, Goodfellow I.
europepmc +1 more source
An Engineered Living Material With Pro‐Angiogenic Activity Inducible by Near‐Infrared Light
Advanced Functional Materials, EarlyView.NIR‐responsive engineered living materials (ELMs) for controlled angiogenesis: Near‐infrared (800 nm) light activates engineered probiotic bacteria within alginate‐based living materials to secrete a blood vessel‐regenerating protein. The released protein promotes pro‐angiogenic effects in endothelial networks and chick chorioallantoic membranes.
Anwesha Chatterjee +4 more
wiley +1 more source
Targeted Protein Degradation for Agricultural Applications: Rationale, Challenges, and Outlook. [PDF]
ACS Bio Med Chem AuFourches D +4 more
europepmc +1 more source
Advanced Functional Materials, EarlyView.We present ultrathin flexible transparent electrodes through iCVD‐enabled molecular control of 10 nm gold films on poly(dimethylaminomethylstyrene). In vivo validation demonstrated photoelectric artifact reduction vs. opaque electrodes and preservation of natural neural dynamics.
Tae Jin Mun +11 more
wiley +1 more source
Nanoparticle-Mediated Targeted Protein Degradation: An Emerging Therapeutics Technology. [PDF]
Angew Chem Int Ed EnglBaker AG, Ho APT, Itzhaki LS, Fruk L.
europepmc +1 more source
Parallel 3D Bioprinting on SLIPS‐Microarrays
Advanced Functional Materials, EarlyView.This work introduces the first truly parallel 3D bioprinting method, enabling both the simultaneous fabrication of hundreds of cell laden hydrogel 3D structures and their HTS in individual liquid compartments. By integrating Digital Light Processing (DLP) stereolithography with functional micropatterns, the platform decouples printing time from array ...
Julius von Padberg +3 more
wiley +1 more source
Dual functionality of MDM2 in PROTACs expands the horizons of targeted protein degradation. [PDF]
Biomark ResZhao J, Chen H, Liang C.
europepmc +1 more source