Results 221 to 230 of about 464,369 (258)

Targeted protein degradation for cancer therapy

Nature Reviews Cancer
Targeted protein degradation (TPD) aims at reprogramming the target specificity of the ubiquitin-proteasome system, the major cellular protein disposal machinery, to induce selective ubiquitination and degradation of therapeutically relevant proteins. Since its conception over 20 years ago, TPD has gained a lot of attention mainly due to improvements ...
Georg E Winter, Alessio Ciulli, Matthias Hinterndorfer   +2 more
exaly   +3 more sources

Targeted Protein Degraders- The Druggability Perspective

Journal of Pharmaceutical Sciences
Targeted Protein degraders (TPDs) show promise in harnessing cellular machinery to eliminate disease-causing proteins, even those previously considered undruggable. Especially if protein turnover is low, targeted protein removal bestows lasting therapeutic effect over typical inhibition.
Satinder, Singh, Pratima, Srivastava
openaire   +2 more sources

Emerging pharmacology of targeted protein degraders

The Journal of Pharmacology and Experimental Therapeutics
Targeted protein degradation is an emerging strategy for experimental and therapeutic ablation of biologically important proteins. To elicit the degradation of their cellular targets, targeted protein degraders act by co-opting the endogenous cellular degradation machineries through chemically-induced proximity.
Samir H. Barghout, Mohamed A. Eldeeb
openaire   +2 more sources

BacPROTACs mediate targeted protein degradation in bacteria

Cell, 2022
Anton Meinhart, Tim Clausen, Robert Kurzbauer   +2 more
exaly  

Targeted protein degradation: A promise for undruggable proteins

Cell Chemical Biology, 2021
Kusal T G Samarasinghe, Craig M. Crews
exaly  

Aptamer-LYTACs for Targeted Degradation of Extracellular and Membrane Proteins

Angewandte Chemie - International Edition, 2023
Chaoyong Yang, Zhi Zhu, Bingqian Lin
exaly  

Targeted Protein Degradation: Clinical Advances in the Field of Oncology

International Journal of Molecular Sciences, 2022
Emilio Casanova, Iris Z Uras
exaly  

Targeted protein degradation in drug development: Recent advances and future challenges

European Journal of Medicinal Chemistry, 2023
Songbo Xie, Tianliang Li
exaly  

Advancing targeted protein degradation modalities

Trends in Pharmacological Sciences, 2023
openaire   +2 more sources

Prey for the Proteasome: Targeted Protein Degradation—A Medicinal Chemist's Perspective

Angewandte Chemie - International Edition, 2020
Philipp M Cromm, Lars Wortmann, Michael Brands   +2 more
exaly