Results 221 to 230 of about 714,957 (298)

Manipulation of targeted protein degradation in plant biology. [PDF]

Biochem Soc Trans
Rojas-Pierce M, Bednarek SY.
europepmc   +1 more source

Multi‐Responsive Dendrimer‐Hyaluronic Acid Hydrogel With Lubricating and Immunoregulatory Functions for Synergistic Osteoarthritis Therapy

Advanced Functional Materials, EarlyView.
A hydrogel with dynamic cross‐links was formed by cross‐linking hyaluronic acid with curcumin‐preloaded, phenylboronic acid‐modified poly(amidoamine) dendrimers. This hydrogel exhibited excellent injectability and self‐healing ability, enabling controlled Cur release in response to low pH, high reactive oxygen species (ROS) generation, or mechanical ...
Junjie Liu, Mengsi Zhan, Haoyu Huang, Jianhong Wang, Cheng Ni, Xiaojun Zhou, Hannah Küttner, Cong Song, Xiangyang Shi, Andrij Pich   +9 more
wiley   +1 more source

Recent advances in glutarimide chemistry for cereblon-mediated targeted protein degradation: developments in synthesis and diversification. [PDF]

RSC Med Chem
Ba X, Dehghany M, Mortensen DS, Holmberg-Douglas N.   +3 more
europepmc   +1 more source

Self‐Assembled Nanoclay Gel With Spheroid MSC‐Derived Exosome Mimetics to Integrate Demineralized Bone Matrix and Noggin‐Targeting miRNA for Synergistic Osteogenesis

Advanced Functional Materials, EarlyView.
We report a versatile nanoclay gel carrier platform that enhances the osteogenic efficacy of demineralized bone matrix (DBM) by integrating nanoclay‐based self‐assembly with cell‐derived exosome mimetics loaded with noggin‐targeting miR‐200c. This design amplifies BMP signaling, thereby promoting DBM‐mediated osteogenesis and offering a promising ...
Changlu Xu, Zhi Li, Minjee Kang, Ruoyu Sheng, Bing Han, Yiqing Chen, Tara Aghaloo, Min Lee   +7 more
wiley   +1 more source

Targeted protein degradation of Wnt/β-catenin signaling pathway: an effective strategy for cancer therapy. [PDF]

J Transl Med
Mao S, Zhang X, Zhao Y, Li X, Wang Z, Zhou P, Wang Z, Zhang X, Hu X, Huang G, Xie W.   +10 more
europepmc   +1 more source

MXene/PEDOT Functional Coatings on Flexible Microelectrode Arrays for Multianalyte In Vivo Neurochemical Sensing and Electrophysiology

Advanced Functional Materials, EarlyView.
A MXene/PEDOT coating enables multimodal functionality and dual‐analyte detection of dopamine and serotonin in flexible microelectrode arrays while enhancing electrophysiological recording quality. The anti‐fouling, low‐impedance interface overcomes key limitations of conventional coatings, providing a robust and versatile platform to investigate the ...
Ilaria Gatti, Karamullah Eisawi, Umisha Siwakoti, Greyson Jadwin, Ashmita Sigdel, Michela Chiappalone, Deepak Kumbhare, Michael Naguib, Elisa Castagnola   +8 more
wiley   +1 more source

Polymeric Lysosome-Targeting Chimeras (PolyTACs): Extracellular Targeted Protein Degradation without Co-Opting Lysosome-Targeting Receptors. [PDF]

J Am Chem Soc
Lu RH, Krishna J, Alp Y, Thayumanavan S.
europepmc   +1 more source

Cyclic Olefin Copolymers as Versatile Materials for Advanced Engineering Applications

Advanced Functional Materials, EarlyView.
Cyclic olefin copolymers (COCs) are presented as highly versatile materials combining tunable synthesis, excellent optical properties, and mechanical robustness. Their potential spans microfluidics, bioengineering, and advanced electronics, while emerging self‐healing and sustainable solutions highlight future opportunities.
Giulia Fredi, Norma Mallegni, Andrea Dorigato, Mario Milazzo   +3 more
wiley   +1 more source

DCAF16-Based Covalent Molecular Glues for Targeted Protein Degradation of Histone Deacetylases. [PDF]

Arch Pharm (Weinheim)
Sun T, Zhai S, Lepper S, König B, Malenica M, Honin I, Hansen FK.   +6 more
europepmc   +1 more source

Coating Artificial Spider Silk Fiber with Magnetic FeCo: An Effective Strategy for Creating a Flexible Magneto‐Responsive Material

Advanced Functional Materials, EarlyView.
An original method is presented for producing artificial spider silk fibers with magnetic and magnetomechanical responsiveness, which consists in coating them with a nanometer‐thick layer of FeCo alloy by sputtering deposition. The challenge of combining organic materials and inorganic magnetic nanostructures is addressed, thus taking a step forward ...
Filippo Lanaro, Federico Spizzo, Gabriele Greco, Benjamin Schmuck, Anna Rising, Lucia Del Bianco   +5 more
wiley   +1 more source