Results 241 to 250 of about 714,957 (298)

Next-Generation Proteolysis-Targeting Chimeras in Precision Oncology: Multifunctional Designs, Emerging Modalities, and Translational Prospects in Targeted Protein Degradation. [PDF]

Drug Dev Res
Nafie MS, Diab MK, Yassen ASA, Elshamy AM, El Tohamy MR, Tawfik HO, Fahmy SA.   +6 more
europepmc   +1 more source

Microfluidic Modeling of Macrophage‐Induced Cardiac Inflammation Using NF‐κB Reporter Cardiomyocytes

Advanced Healthcare Materials, EarlyView.
A cardiac inflammation model was developed to enable real‐time analysis of macrophage‐cardiomyocyte interactions using NF‐κB‐reporter cardiomyocytes and a microfluidic co‐culture system. A MATLAB‐based model was implemented to optimize cell density and medium resupply based on TNFα diffusion kinetics. Activation thresholds and stress responses in NF‐κB‐
Chao Liu, Xi Rui Qiang Lu, Seoyoung Jeong, Douglas H. Wu, Rodrigo A. Somoza, Parameswaran Ramakrishnan, Samuel E. Senyo   +6 more
wiley   +1 more source

Aqueous Two‐Phase Bioinks for Discrete Packing and Compartmentalization of 3D Bioprinted Cells

Advanced Healthcare Materials, EarlyView.
Aqueous two‐phase systems (ATPS) enable the formation of biomimetic interfaces crucial for tissue engineering. However, clinical translation remains limited by the challenge of precisely controlling cellular compartmentalization. Here, we developed ATPS biomaterial inks for 3D bioprinting allowing tuneable droplet formation via NaCl modulation.
Martina Marcotulli, Arianna Iacomino, Federico Serpe, Lucia Iafrate, Marco Bastioli, Giorgia Montalbano, Michele D'Orazio, Biagio Palmisano, Silvia Franco, Arianna Mencattini, Roberta Angelini, Eugenio Martinelli, Alessandro Corsi, Mara Riminucci, Giancarlo Ruocco, Chiara Scognamiglio, Andrea Barbetta, Gianluca Cidonio   +17 more
wiley   +1 more source

Author Correction: Identification of a non-inhibitory aptameric ligand to CRL2^ZYG11B E3 ligase for targeted protein degradation. [PDF]

Nat Commun
Yang Z, Chen M, Ge R, Zhou P, Pan W, Song J, Ma S, Chen S, Xu C, Zhou M, Mi W, Ni H, Chen H, Yao X, Dong X, Chen Y, Zhou J, Xuan C, Dong C, Yan H, Xie S.   +20 more
europepmc   +1 more source

Targeted Protein Degradation of the Latency-Associated Nuclear Antigen Evicts Kaposi Sarcoma-Associated Herpesvirus Episomes From Infected Cells In Vitro. [PDF]

J Med Virol
McMahon S, Amer M, Hall B, Shekhar R, Renne R.   +4 more
europepmc   +1 more source

Harnessing the FBXW7 Somatic Mutant R465C for Targeted Protein Degradation. [PDF]

J Am Chem Soc
Basu AA, Zhang C, Rouhimoghadam M, Vasudevan A, Reitsma JM, Zhang X.   +5 more
europepmc   +1 more source

Targeted protein degradation by KLHDC2 ligands identified by high-throughput screening. [PDF]

Elife
Zhou H, Zhou T, Yu W, Liu L, Ko Y, Johnson KA, Wilson IA, Schultz PG, Bollong MJ.   +8 more
europepmc   +1 more source

Toward Anti-Herpesviral PROTACs: Assessing the Challenges for Targeted Protein Degradation on the Example of Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen. [PDF]

ChemMedChem
Berwanger A, Stein SC, Brandner S, Kany AM, Heinz S, Loretz B, Lehr CM, Hirsch AKH, Lermyte F, Schulz TF, Empting M.   +10 more
europepmc   +1 more source

Data-independent acquisition (DIA) approach for comprehensive ubiquitinome profiling in targeted protein degradation

Sathe G, Röth S, Gelders G, Brewer A, Macartney TJ, Wood NT, De Muynck L, Nakasone MA, Phung TK, Buist A, Moechars D, Sapkota GP.   +11 more
europepmc   +1 more source

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Monomeric Targeted Protein Degraders

Journal of Medicinal Chemistry, 2020
The discovery and development of targeted protein degraders have become important areas of research in the field of medicinal chemistry. Inducing degradation of a target protein presents several advantages relative to simple inhibition including a potential for extended duration of action and more profound pharmacology.
Emily J. Hanan, Jun Liang, Xiaojing Wang, Robert A. Blake, Nicole Blaquiere, Steven T. Staben   +5 more
openaire   +2 more sources