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Next steps for targeted protein degradation
Cell Chemical BiologyTargeted protein degradation (TPD) has greatly advanced as a therapeutic strategy in the past two decades, and we are on the cusp of rationally designed protein degraders reaching clinical approval. Offering pharmacological advantages relative to occupancy-driven protein inhibition, chemical methods for regulating biomolecular proximity have provided ...
Mackenzie W. Krone, Craig M. Crews
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The promise of targeted protein degradation approaches
Trends in Pharmacological Sciences, 2023Daniels, Danette +2 more
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Targeted Protein Degraders- The Druggability Perspective
Journal of Pharmaceutical SciencesTargeted Protein degraders (TPDs) show promise in harnessing cellular machinery to eliminate disease-causing proteins, even those previously considered undruggable. Especially if protein turnover is low, targeted protein removal bestows lasting therapeutic effect over typical inhibition.
Satinder, Singh, Pratima, Srivastava
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Targeted protein degradation: A promise for undruggable proteins
Cell Chemical Biology, 2021Kusal T G Samarasinghe, Craig M Crews
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Extracellular targeted protein degradation: an emerging modality for drug discovery
Nature Reviews Drug Discovery, 2023James A Wells
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Targeted Protein Degradation: Clinical Advances in the Field of Oncology
International Journal of Molecular Sciences, 2022Emilio Casanova, Iris Z Uras
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Prey for the Proteasome: Targeted Protein Degradation—A Medicinal Chemist's Perspective
Angewandte Chemie - International Edition, 2020Lars Wortmann +2 more
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Targeted Protein Degradation Technology and Nanomedicine: Powerful Allies against Cancer
Small, 2023Dale G Nagle, Xin Luan
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