Results 11 to 20 of about 5,184,182 (156)

Targeted Protein Degradation (TPD) for Immunotherapy: Understanding Proteolysis Targeting Chimera-Driven Ubiquitin-Proteasome Interactions. [PDF]

Bioconjug Chem
Targeted protein degradation or TPD, is rapidly emerging as a treatment that utilizes small molecules to degrade proteins that cause diseases. TPD allows for the selective removal of disease-causing proteins, including proteasome-mediated degradation, lysosome-mediated degradation, and autophagy-mediated degradation.
Kamaraj R, Ghosh S, Das S, Sen S, Kumar P, Majumdar M, Dasgupta R, Mukherjee S, Das S, Ghose I, Pavek P, Raja Karuppiah MP, Chuturgoon AA, Anand K.   +13 more
europepmc   +7 more sources

Beyond canonical PROTAC: biological targeted protein degradation (bioTPD)

Biomaterials Research, 2023
Targeted protein degradation (TPD) is an emerging therapeutic strategy with the potential to modulate disease-associated proteins that have previously been considered undruggable, by employing the host destruction machinery. The exploration and discovery
Huifang Wang, Runhua Zhou, Fushan Xu, Kongjun Yang, Liuhai Zheng, Pan Zhao, Guangwei Shi, Lingyun Dai, Chengchao Xu, Le Yu, Zhijie Li, Jianhong Wang, Jigang Wang   +12 more
doaj   +2 more sources

Targeted protein degradation in hematologic malignancies: clinical progression towards novel therapeutics

Biomarker Research
Targeted therapies, such as small molecule kinase inhibitors, have made significant progress in the treatment of hematologic malignancies by directly modulating protein activity.
Yupiao Feng, Xinting Hu, Xin Wang
doaj   +2 more sources

Machine Learning Modeling of Protein-intrinsic Features Predicts Tractability of Targeted Protein Degradation [PDF]

Genomics, Proteomics & Bioinformatics, 2022
Targeted protein degradation (TPD) has rapidly emerged as a therapeutic modality to eliminate previously undruggable proteins by repurposing the cell’s endogenous protein degradation machinery. However, the susceptibility of proteins for targeting by TPD
Wubing Zhang, Shourya S. Roy Burman, Jiaye Chen, Katherine A. Donovan, Yang Cao, Chelsea Shu, Boning Zhang, Zexian Zeng, Shengqing Gu, Yi Zhang, Dian Li, Eric S. Fischer, Collin Tokheim, X. Shirley Liu   +13 more
doaj   +2 more sources

Extracellular vesicle-based targeted protein degradation platform for multiple extracellular proteins

EMBO Molecular Medicine
Targeted protein degradation (TPD) is an emerging therapeutic approach that enables the degradation of undruggable targets via intracellular degradation systems.
Bide Tong, Xiaoguang Zhang, Dingchao Zhu, Yulei Wang, Junyu Wei, Zixuan Ou, Huaizhen Liang, Hanpeng Xu, Zhengdong Zhang, Jie Lei, Xingyu Zhou, Di Wu, Yu Song, Kun Wang, Xiaobo Feng, Lei Tan, Zhiwei Liao, Cao Yang   +17 more
doaj   +2 more sources

The application of drug delivery systems based on targeted protein degradation chimeras in disease treatment strategies [PDF]

Journal of Nanobiotechnology
In recent years, the technology of targeted protein degradation (TPD) has developed rapidly. Proteolysis targeting chimeras (PROTACs) have achieved remarkable results in the specific clearance of target proteins through the ubiquitin-proteasome system ...
Weiqi Lin, Enqi Qiao, Zhongkai Wang, Chunqing Tang, Chenghui Li, Jian Lu   +5 more
doaj   +2 more sources

The degradation revolution: harnessing targeted protein degradation for the treatment of human diseases [PDF]

Cellular and Molecular Life Sciences
Targeted protein degradation (TPD) redefines therapeutic strategies by overcoming the key limitations of traditional occupancy-driven pharmacology. TPD introduces a paradigm shift by using the cell’s intrinsic degradation systems—primarily the ubiquitin ...
Jie Tong, Peng Wang, Saiya Ma, Jing Li, Yufei Zhan, Mengxuan Liu, Feng Jin, Guosheng Qu, Chunfu Zheng, Xiaochun Wang, Chuan Wang   +10 more
doaj   +2 more sources

Targeted protein degradation: advances in drug discovery and clinical practice

Signal Transduction and Targeted Therapy
Targeted protein degradation (TPD) represents a revolutionary therapeutic strategy in disease management, providing a stark contrast to traditional therapeutic approaches like small molecule inhibitors that primarily focus on inhibiting protein function.
Guangcai Zhong, Xiaoyu Chang, Weilin Xie, Xiangxiang Zhou   +3 more
doaj   +2 more sources

Extracellular and Membrane Protein: Structure, Biological Functions, Diseases, and an Emerging Modality for Drug Discovery [PDF]

MedComm
Extracellular and membrane proteins serve important roles. They manage cellular communication, structure support, and immune defense. When they malfunction, it cause many diseases like cancer, neurodegeneration, and cardiovascular disorders.
Mengqing Zhao, Wenhao Yin, Jianjian Han, Huimin Wang, Zheng Liu, Lilong Liu, Wuxiang Mao   +6 more
doaj   +2 more sources

Targeted protein degradation in mycobacteria uncovers antibacterial effects and potentiates antibiotic efficacy

Nature Communications
Proteolysis-targeting chimeras (PROTACs) represent a new therapeutic modality involving selectively directing disease-causing proteins for degradation through proteolytic systems.
Harim I. Won, Samuel Zinga, Olga Kandror, Tatos Akopian, Ian D. Wolf, Jessica T. P. Schweber, Ernst W. Schmid, Michael C. Chao, Maya Waldor, Eric J. Rubin, Junhao Zhu   +10 more
doaj   +2 more sources