Results 31 to 40 of about 5,184,182 (156)

Nanotechnology-Enabled Targeted Protein Degradation: Strategies, Opportunities, and Challenges. [PDF]

Small Methods
Targeted protein degradation (TPD) has redefined the therapeutic landscape by shifting the focus from merely inhibiting protein function to actively eliminating disease‐causing proteins. However, the clinical translation of TPD agents remains hampered by
Zhu H, Zhang Y, Ning Y, Yang C, Zhang G, Zhu Z.   +5 more
europepmc   +2 more sources

Research advances in targeted protein degradation technologies [PDF]

Yixue xinzhi zazhi
Targeted protein degradation (TPD) technologies leverage the body’s innate protein degradation systems to selectively eliminate protein of interest (POI).
PI Chuan, HAO Xuanrun, XIAO Haiting, LUO Xing, ZHANG Qixiong   +4 more
doaj   +1 more source

Expanding PROTACtable genome universe of E3 ligases

Nature Communications, 2023
Proteolysis-targeting chimera (PROTAC) and other targeted protein degradation (TPD) molecules that induce degradation by the ubiquitin-proteasome system (UPS) offer new opportunities to engage targets that remain challenging to be inhibited by ...
Yuan Liu, Jingwen Yang, Tianlu Wang, Mei Luo, Yamei Chen, Chengxuan Chen, Ze’ev Ronai, Yubin Zhou, Eytan Ruppin, Leng Han   +9 more
doaj   +1 more source

The contribution of native protein complexes to targeted protein degradation

Targeted protein degradation (TPD) destroys proteins of interest (POIs) by hijacking the cellular proteolytic machinery. Most proteins in cells exist and function as part of multi-protein or macromolecular complexes, thereby allowing a single protein to ...
Woo, Christina, Centre for Targeted Protein Degradation, Sathe, Gajanan, Macartney, Thomas, Curnutt, Nicole, Zhao, Jin-Feng, Le Chatelier, Brune, Dunbar, Karen, Glennie, Lorraine, Harvard University, Columbia University, Cartwright, Tyrell, Wood, Nicola, Goff, Freya, MRC PPU, Sapkota, Gopal   +15 more
core   +3 more sources

Harnessing the Anaphase-Promoting Complex for Targeted Protein Degradation [PDF]

, 2023
Targeted protein degradation (TPD) is rapidly becoming a prevalent modality of therapeutics development due to its event-driven pharmacology that overcomes some major limitations of conventional small molecule inhibitors.

core   +2 more sources

Molecular glues: The adhesive connecting targeted protein degradation to the clinic [PDF]

, 2022
Targeted protein degradation is a rapidly exploding drug discovery strategy which uses small molecules to recruit disease-causing proteins for rapid destruction mainly via the ubiquitin-proteasome pathway.
Janet M., Sasso, Qiongqiong Angela, Zhou, Linda S., Johnson, Xinmei, Wang, DaSheng, Wang, Rumiana, Tenchov   +5 more
core   +2 more sources

Targeted protein degradation: novel pharmacological approach for unmet medical needs

This is a brief summary of various general contemporary topics regarding targeted protein degradation ...
Plata, Carlos
core   +4 more sources

Assembly/disassembly-based targeting protein degradation systems for cancer therapy

EngMedicine
Targeted protein degradation (TPD) is an innovative strategy for selectively eliminating pathogenic proteins, enabling precise degradation of once-undruggable targets in cancer therapy.
Hongzhe Yan, Xiaoyang Liu, Ying Xu, Gaolin Liang, Xiaofeng Wu   +4 more
doaj   +1 more source

Induced polyubiquitination of proteins mediated by overexpression of a peptide: a novel tool for targeted protein degradation (TPD) research.

, 2022
Abstract A novel strategy for targeting proteins with peptides which give rise to stable ubiquitination has been identified with proteomics. Several bioactive peptides gave rise to characteristic patterns of polyubiquitinated proteins, containing distinct sets of proteins in a cell culture model.
openaire   +1 more source

Ligandability of E3 Ligases for Targeted Protein Degradation Applications.

, 2021
Targeted protein degradation (TPD) using proteolysis targeting chimeras (PROTACs) and molecular glue degraders has arisen as a powerful therapeutic modality for eliminating disease-causing proteins from cells.
Nomura, Daniel, Ward, Carl, Belcher, Bridget   +2 more
core   +3 more sources